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Query: KDM6A

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KDM6A 0 0.654 1.910 -0.840 -0.542 -0.153
KDM6A 0 0.654 1.910 -0.840 -0.406 0.870

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KDM6A Phosphorylation T879 -0.585 0.018 _TDNSVASS(ph)PSSAISTAT(ph)PSPK_
KDM6A Phosphorylation S870 0.867 -0.013 _TDNSVASS(ph)PSSAISTATPSPK_
KDM6A Phosphorylation S866 -0.439 _TDNS(ph)VASSPSSAISTATPS(ph)PK_
KDM6A Phosphorylation S881 -0.285 -0.548 _TDNSVASS(ph)PSSAISTATPS(ph)PK_
KDM6A Phosphorylation S872 0.757 _TDNSVASSPS(ph)SAISTATPSPK_
KDM6A Phosphorylation S876 -0.001 _TDNSVAS(ph)SPSSAIS(ph)TATPSPK_

Background Information for KDM6A:


Pubmed-KDM6A »
Uniprot-KDM6A »
Biogrid-KDM6A »
ProteomicsDB-KDM6A »

Tumorportal-KDM6A »
COSMIC-KDM6A »
GenomeRNAi-KDM6A »
Genecards-KDM6A


Protein-protein Interactions for KDM6A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARHGAP22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KDM6A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TPR_1 IPR001440 1.39
Category members TPR-contain_dom IPR013026 0.97
Category members TPR_repeat IPR019734 0.93
Category members JmjC_dom IPR003347 0


Protein complexes (CORUM database) featuring KDM6A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5195 PTIP-HMT complex Database 0.33
Category members Corum 3075 UTX-MLL2/3 complex Database 0


Categories featuring KDM6A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0051568 histone H3-K4 methylation Database 1.7
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0035097 histone methyltransferase complex Database 0.26
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0003016 respiratory system process Database 0.17
Category members Disease phenotype Kabuki_syndrome Kabuki syndrome Database 0.13
Category members GO Category GO:0051213 dioxygenase activity Database 0.08
Category members GO Category GO:0048333 mesodermal cell differentiation Database 0.03
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0032525 somite rostral/caudal axis specification Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048570 notochord morphogenesis Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0


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