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Query: KDM5A

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
KDM5A 0 -0.331 0.183 -0.131

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
KDM5A Phosphorylation S1111 -0.424 0.369 _DLDLEPLS(ph)DLEEGLEETR_
KDM5A Ubiquitylation K805 -0.328 _EAETCASVAQLLLSKK(gl)_
KDM5A Ubiquitylation K159 -0.589 _GTGSLLK(gl)SHYER_
KDM5A Ubiquitylation K135 -0.691 _GGFEMVTK(gl)EK_
KDM5A Ubiquitylation K137 -0.691 _GGFEMVTK(gl)EK_
KDM5A Phosphorylation S1666 -1.341 _KQGPVS(ph)PGPAPPPSFIMSYK_

Background Information for KDM5A:


Pubmed-KDM5A »
Uniprot-KDM5A »
Biogrid-KDM5A »
ProteomicsDB-KDM5A »

Tumorportal-KDM5A »
COSMIC-KDM5A »
GenomeRNAi-KDM5A »
Genecards-KDM5A


Protein-protein Interactions for KDM5A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GATAD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KDM5A Cat. description Hein, Mann, Cell 2015
Category members IP bait PHF12 Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM8A Cat. description Hein, Mann, Cell 2015
Category members IP bait RCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SIN3B Cat. description Hein, Mann, Cell 2015
Category members IP bait TM9SF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MORF4L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in KDM5A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_FYVE_PHD IPR011011 1.23
Category members Znf_PHD IPR001965 1.15
Category members Znf_PHD-finger IPR019787 0.91
Category members Znf_C5HC2 IPR004198 0.33
Category members Lys_sp_deMease_like_dom IPR013637 0.18
Category members TF_JmjN IPR003349 0.08
Category members ARID/BRIGHT_DNA-bd IPR001606 0
Category members JmjC_dom IPR003347 0


Protein complexes (CORUM database) featuring KDM5A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring KDM5A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex Database 0.3
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members Disease phenotype Autosomal_Recessive_Mental_Retardation Autosomal Recessive Mental Retardation Database 0
Category members GO Category GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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