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bioLOGIC Data

Query: KAT8

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
KAT8	0	-2.443	-0.610	0.360

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
KAT8	Phosphorylation	S37		-2.803	_(ac)AAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPS(ph)PGRVS(ph)PPTPAR_
KAT8	Phosphorylation	S42		-2.803	_(ac)AAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPS(ph)PGRVS(ph)PPTPAR_

Background Information for KAT8:

Pubmed-KAT8 »

Uniprot-KAT8 »

Biogrid-KAT8 »

ProteomicsDB-KAT8 »

Tumorportal-KAT8 »

COSMIC-KAT8 »

GenomeRNAi-KAT8 »

Genecards-KAT8

Protein-protein Interactions for KAT8

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait KAT8	Cat. description	Hein, Mann, Cell 2015

Protein Domains in KAT8

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	Chromo_domain/shadow	IPR000953	2.84
Category members	Chromodomain-like	IPR016197	2.29
Category members	MOZ_SAS	IPR002717	0.02
Category members	Tudor-knot	IPR025995	0.01
Category members	Acyl_CoA_acyltransferase	IPR016181	0

Protein complexes (CORUM database) featuring KAT8

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	5386	MLL1-WDR5 complex	Database	0.31
Category members	Corum	1401	MOF complex	Database	0.09
Category members	Corum	610	MSL complex	Database	0

Categories featuring KAT8

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	Pathway	Pathway_416	PID_P53_REGULATION_PATHWAY	0	2.29
Category members	GO Category	GO:0000776	kinetochore	Database	2.24
Category members	GO Category	GO:0019899	enzyme binding	Database	1.57
Category members	GO Category	GO:0016573	histone acetylation	Database	1.24
Category members	GO Category	GO:0045892	negative regulation of transcription, DNA-dependent	Database	1.15
Category members	GO Category	GO:0006351	transcription, DNA-templated	Database	1.07
Category members	GO Category	GO:0004402	histone acetyltransferase activity	Database	0.56
Category members	GO Category	GO:0035064	methylated histone residue binding	Database	0.53
Category members	GO Category	GO:0071339	MLL1 complex	Database	0.45
Category members	GO Category	GO:0043981	histone H4-K5 acetylation	Database	0.43
Category members	GO Category	GO:0043982	histone H4-K8 acetylation	Database	0.43
Category members	GO Category	GO:0008134	transcription factor binding	Database	0.37
Category members	GO Category	GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups	Database	0.33
Category members	GO Category	GO:0045893	positive regulation of transcription, DNA-dependent	Database	0.28
Category members	GO Category	GO:0000123	histone acetyltransferase complex	Database	0.15
Category members	GO Category	GO:0043984	histone H4-K16 acetylation	Database	0.07
Category members	GO Category	GO:0016407	acetyltransferase activity	Database	0.05
Category members	GO Category	GO:0043995	histone acetyltransferase activity (H4-K5 specific)	Database	0.04
Category members	GO Category	GO:0043996	histone acetyltransferase activity (H4-K8 specific)	Database	0.04
Category members	GO Category	GO:0046972	histone acetyltransferase activity (H4-K16 specific)	Database	0.04
Category members	GO Category	GO:0006355	regulation of transcription, DNA-dependent	Database	0
Category members	GO Category	GO:0030099	myeloid cell differentiation	Database	0
Category members	GO Category	GO:0046872	metal ion binding	Database	0