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Query: IQGAP2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IQGAP2 0 -0.490 0.570 -0.600 -0.934 -0.237 -0.246 0.574 0.202

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IQGAP2 Phosphorylation S16 0.126 0.190 _YGS(ph)IVDDER_
IQGAP2 Ubiquitylation K837 -0.165 _IGLLVK(gl)NR_

Background Information for IQGAP2:


Pubmed-IQGAP2 »
Uniprot-IQGAP2 »
Biogrid-IQGAP2 »
ProteomicsDB-IQGAP2 »

Tumorportal-IQGAP2 »
COSMIC-IQGAP2 »
GenomeRNAi-IQGAP2 »
Genecards-IQGAP2


Protein-protein Interactions for IQGAP2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MAGEA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUCLA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IQGAP2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members WW_dom IPR001202 1.15
Category members CH-domain IPR001715 0.63
Category members Rho_GTPase_activation_prot IPR008936 0.53
Category members RasGAP IPR001936 0.19
Category members IQ_motif_EF-hand-BS IPR000048 0
Category members RasGAP_C IPR000593 0


Protein complexes (CORUM database) featuring IQGAP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5220 CHUK-IQGAP2-AKAP8L-RELA-TNIP2 complex Database 0.4
Category members Corum 5233 TNF-alpha/NF-kappa B signaling complex 5 Database 0.29


Categories featuring IQGAP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members GO Category GO:0005902 microvillus Database 0.13
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0005095 GTPase inhibitor activity Database 0.05
Category members GO Category GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding Database 0.04
Category members GO Category GO:0005099 Ras GTPase activator activity Database 0.02
Category members GO Category GO:0007165 signal transduction Database 0


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