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Query: IGF2BP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IGF2BP1 2 4.011 0.480 -0.920 -0.339 0.012 0.258 -0.196 0.244

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IGF2BP1 Ubiquitylation K475 1.590 2.237 _LK(gl)EENFFGPK_
IGF2BP1 Ubiquitylation K346 0.773 _AEQEIMKK(gl)_
IGF2BP1 Ubiquitylation K330 0.912 0.577 _TITVK(gl)GAIENCCR_
IGF2BP1 Phosphorylation S313 0.221 _ITIS(ph)SLQDLTLYNPER_
IGF2BP1 Phosphorylation S181 0.145 0.078 _QGS(ph)PVAAGAPAK_
IGF2BP1 Ubiquitylation K294 -0.976 0.052 _LIGK(gl)EGR_
IGF2BP1 Ubiquitylation K561 -0.386 0.027 _DILAQVK(gl)QQHQK_
IGF2BP1 Ubiquitylation K66 0.468 0.007 _VELQGK(gl)R_
IGF2BP1 Ubiquitylation K465 -0.956 -0.267 _MVIITGPPEAQFK(gl)AQGR_
IGF2BP1 Ubiquitylation K272 -1.062 -0.765 _DTK(gl)TADEVPLK_
IGF2BP1 Ubiquitylation K190 -2.143 -1.004 _QGSPVAAGAPAK(gl)QQQVDIPLR_
IGF2BP1 Ubiquitylation K440 -1.281 -1.065 _FASASIK(gl)IAPPETPDSK_
IGF2BP1 Ubiquitylation K450 -1.512 -1.678 _IAPPETPDSK(gl)VR_
IGF2BP1 Ubiquitylation K300 -0.107 _NLK(gl)KVEQDTETK_
IGF2BP1 Phosphorylation S314 0.255 _ITISS(ph)LQDLTLYNPER_
IGF2BP1 Ubiquitylation K429 0.375 _GQHIK(gl)QLSR_

Background Information for IGF2BP1:


Pubmed-IGF2BP1 »
Uniprot-IGF2BP1 »
Biogrid-IGF2BP1 »
ProteomicsDB-IGF2BP1 »

Tumorportal-IGF2BP1 »
COSMIC-IGF2BP1 »
GenomeRNAi-IGF2BP1 »
Genecards-IGF2BP1


Protein-protein Interactions for IGF2BP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait ELAVL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GSPT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IGF2BP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members KH_dom IPR004087 0.23
Category members KH_dom_type_1 IPR004088 0.13


Protein complexes (CORUM database) featuring IGF2BP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3055 Nop56p-associated pre-rRNA complex Database INF


Categories featuring IGF2BP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0051028 mRNA transport Database 1.7
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0010494 cytoplasmic stress granule Database 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0070934 CRD-mediated mRNA stabilization Database 0.7
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0006403 RNA localization Database 0.49
Category members GO Category GO:0070937 CRD-mediated mRNA stability complex Database 0.44
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0017148 negative regulation of translation Database 0.34
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0003730 mRNA 3'-UTR binding Database 0.24
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0045182 translation regulator activity Database 0.18
Category members GO Category GO:0048027 mRNA 5'-UTR binding Database 0.08
Category members GO Category GO:0030175 filopodium Database 0.05
Category members GO Category GO:0042035 regulation of cytokine biosynthetic process Database 0


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