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Query: HSD17B4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSD17B4 1 1.674 0.150 -0.410 0.662 1.589 0.132 0.014

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSD17B4 Ubiquitylation K68 -0.723 _GGK(gl)AVANYDSVEEGEK_

Background Information for HSD17B4:


Pubmed-HSD17B4 »
Uniprot-HSD17B4 »
Biogrid-HSD17B4 »
ProteomicsDB-HSD17B4 »

Tumorportal-HSD17B4 »
COSMIC-HSD17B4 »
GenomeRNAi-HSD17B4 »
Genecards-HSD17B4


Protein-protein Interactions for HSD17B4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FOS Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPD Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait MTX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RACGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IKZF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSD17B4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SCP2_sterol-bd_dom IPR003033 0.04
Category members DH_sc/Rdtase_SDR IPR002198 0
Category members Glc/ribitol_DH IPR002347 0
Category members DHB_DH IPR003560 0
Category members PKS_KR IPR013968 0
Category members PKS/FAS_KR IPR020842 0
Category members HotDog_dom IPR029069 0


Protein complexes (CORUM database) featuring HSD17B4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HSD17B4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0016853 isomerase activity Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase Database 0.23
Category members GO Category GO:0005782 peroxisomal matrix Database 0.23
Category members Disease phenotype Perrault_syndrome Perrault syndrome Database 0.11
Category members Disease phenotype Bifunctional_enzyme_deficiency Bifunctional enzyme deficiency Database 0.08
Category members Pathway Pathway_143 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM 0 0.07
Category members GO Category GO:0008210 estrogen metabolic process Database 0.07
Category members GO Category GO:0033559 unsaturated fatty acid metabolic process Database 0.07
Category members GO Category GO:0036109 alpha-linolenic acid metabolic process Database 0.07
Category members Pathway Pathway_26 REACTOME_PEROXISOMAL_LIPID_METABOLISM 0 0.04
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0032934 sterol binding Database 0.04
Category members GO Category GO:0060009 Sertoli cell development Database 0.03
Category members GO Category GO:0005778 peroxisomal membrane Database 0.01
Category members Pathway Pathway_167 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL 0 0
Category members Pathway Pathway_168 REACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM 0 0
Category members Pathway Pathway_169 KEGG_PRIMARY_BILE_ACID_BIOSYNTHESIS 0 0
Category members Pathway Pathway_170 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS 0 0
Category members Pathway Pathway_25 KEGG_PEROXISOME 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members GO Category GO:0000038 very long-chain fatty acid metabolic process Database 0
Category members GO Category GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0005777 peroxisome Database 0
Category members GO Category GO:0006635 fatty acid beta-oxidation Database 0
Category members GO Category GO:0006699 bile acid biosynthetic process Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0008206 bile acid metabolic process Database 0
Category members GO Category GO:0008209 androgen metabolic process Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016508 long-chain-enoyl-CoA hydratase activity Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0


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