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Query: HPRT1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HPRT1 0 2.220 -0.840 0.070 -0.388 0.526
HPRT1 0 2.220 -0.840 0.070 1.039

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HPRT1 Ubiquitylation K159 0.923 0.525 _MVK(gl)VASLLVK_
HPRT1 Ubiquitylation K103 0.354 -0.199 _LK(gl)SYCNDQSTGDIK_
HPRT1 Ubiquitylation K166 -0.029 -0.428 _VASLLVK(gl)R_
HPRT1 Ubiquitylation K215 0.354 -0.516 _DLNHVCVISETGKAK(gl)_
HPRT1 Phosphorylation S5 -0.474 _S(ph)PGVVISDDEPGYDLDLFCIPNHYAEDLER_
HPRT1 Ubiquitylation K175 -1.570 _SVGYK(gl)PDFVGFEIPDK_

Background Information for HPRT1:


Pubmed-HPRT1 »
Uniprot-HPRT1 »
Biogrid-HPRT1 »
ProteomicsDB-HPRT1 »

Tumorportal-HPRT1 »
COSMIC-HPRT1 »
GenomeRNAi-HPRT1 »
Genecards-HPRT1


Protein-protein Interactions for HPRT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HPRT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HPRT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PRTase-like IPR029057 0.32
Category members PRibTrfase_dom IPR000836 0.08
Category members Hxn_phspho_trans IPR005904 0


Protein complexes (CORUM database) featuring HPRT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HPRT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0051289 protein homotetramerization Database 0.44
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0048813 dendrite morphogenesis Database 0.23
Category members Pathway Pathway_204 REACTOME_PURINE_METABOLISM 0 0.22
Category members GO Category GO:0006144 purine nucleobase metabolic process Database 0.11
Category members GO Category GO:0006168 adenine salvage Database 0.11
Category members GO Category GO:0007610 behavior Database 0.04
Category members GO Category GO:0021954 central nervous system neuron development Database 0.02
Category members Pathway Pathway_205 REACTOME_PURINE_SALVAGE 0 0
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_77 KEGG_DRUG_METABOLISM_OTHER_ENZYMES 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0001975 response to amphetamine Database 0
Category members GO Category GO:0004422 hypoxanthine phosphoribosyltransferase activity Database 0
Category members GO Category GO:0006164 purine nucleotide biosynthetic process Database 0
Category members GO Category GO:0006166 purine ribonucleoside salvage Database 0
Category members GO Category GO:0007625 grooming behavior Database 0
Category members GO Category GO:0007626 locomotory behavior Database 0
Category members GO Category GO:0009116 nucleoside metabolic process Database 0
Category members GO Category GO:0019835 cytolysis Database 0
Category members GO Category GO:0021756 striatum development Database 0
Category members GO Category GO:0021895 cerebral cortex neuron differentiation Database 0
Category members GO Category GO:0032264 IMP salvage Database 0
Category members GO Category GO:0042417 dopamine metabolic process Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043101 purine-containing compound salvage Database 0
Category members GO Category GO:0043103 hypoxanthine salvage Database 0
Category members GO Category GO:0045964 positive regulation of dopamine metabolic process Database 0
Category members GO Category GO:0046040 IMP metabolic process Database 0
Category members GO Category GO:0046651 lymphocyte proliferation Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0


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