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Query: HMGA1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HMGA1 2 4.567 -0.300 0.610
HMGA1 2 4.567 -0.300 0.610 -1.084 -0.264

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HMGA1 Phosphorylation S8 2.198 2.240 _(ac)SESSSKS(ph)SQPLASK_
HMGA1 Phosphorylation S9 1.976 2.155 _(ac)SESSSKSS(ph)QPLASK_
HMGA1 Phosphorylation S2 -0.266 1.155 _(ac)S(ph)ESSSKS(ph)SQPLASK_
HMGA1 Ubiquitylation K7 0.088 0.752 _(ac)SESSSK(gl)SSQPLASK_
HMGA1 Phosphorylation S4 0.519 _(ac)SES(ph)SSKS(ph)SQPLASK_
HMGA1 Phosphorylation S103 0.370 _EEEEGISQESS(ph)EEEQ_
HMGA1 Phosphorylation S6 0.475 0.368 _(ac)SESSS(ph)KSSQPLASK_
HMGA1 Phosphorylation S5 0.398 0.365 _(ac)SESS(ph)SKSSQPLASK_
HMGA1 Phosphorylation S49 -2.923 0.166 _KQPPVSPGTALVGSQKEPS(ph)EVPTPK_
HMGA1 Phosphorylation S44 -0.035 0.111 _KQPPVSPGTALVGS(ph)QKEPSEVPTPK_
HMGA1 Phosphorylation S102 -0.522 -0.117 _KLEKEEEEGISQES(ph)SEEEQ_
HMGA1 Ubiquitylation K15 0.114 -0.136 _SSQPLASK(gl)QEKDGTEK_
HMGA1 Ubiquitylation K18 0.073 -0.136 _SSQPLASKQEK(gl)_
HMGA1 Phosphorylation S36 -1.043 -0.690 _KQPPVS(ph)PGTALVGSQK_
HMGA1 Phosphorylation T42 -2.456 -2.027 _KQPPKEPSEVPT(ph)PK_
HMGA1 Phosphorylation T53 -2.612 -2.477 _KQPPVSPGTALVGSQKEPSEVPT(ph)PK_
HMGA1 Ubiquitylation K46 -1.742 _KQPPVSPGTALVGSQK(gl)EPSEVPTPK_

Background Information for HMGA1:


Pubmed-HMGA1 »
Uniprot-HMGA1 »
Biogrid-HMGA1 »
ProteomicsDB-HMGA1 »

Tumorportal-HMGA1 »
COSMIC-HMGA1 »
GenomeRNAi-HMGA1 »
Genecards-HMGA1


Protein-protein Interactions for HMGA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AP4M1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CSK Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBL Cat. description Hein, Mann, Cell 2015
Category members IP bait GSPT1;GSPT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIFC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RACGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZSCAN5A Cat. description Hein, Mann, Cell 2015


Protein Domains in HMGA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMGI/HMGY IPR000116 0.08
Category members AT_hook_DNA-bd_motif IPR017956 0
Category members AT_hook-like IPR020478 0


Protein complexes (CORUM database) featuring HMGA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HMGA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_1206 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS 0 6.87
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006337 nucleosome disassembly Database 3
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_859 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE 0 1.34
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_981 REACTOME_INTEGRATION_OF_PROVIRUS 0 0.76
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0035985 senescence-associated heterochromatin focus Database 0.26
Category members GO Category GO:0035986 senescence-associated heterochromatin focus assembly Database 0.26
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006268 DNA unwinding involved in DNA replication Database 0.19
Category members GO Category GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity Database 0.16
Category members GO Category GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Database 0.12
Category members GO Category GO:0042975 peroxisome proliferator activated receptor binding Database 0.05
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members GO Category GO:0042974 retinoic acid receptor binding Database 0.02
Category members Pathway Pathway_1313 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION 0 0
Category members Pathway Pathway_419 PID_IL4_2PATHWAY 0 0
Category members GO Category GO:0003680 AT DNA binding Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0046965 retinoid X receptor binding Database 0
Category members GO Category GO:0051575 5'-deoxyribose-5-phosphate lyase activity Database 0


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