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Query: HLA-E

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HLA-E 0 0.061 1.660 -0.940

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HLA-E Ubiquitylation K384 0.061 _GGSYSK(gl)AEWSDSAQGSESHSL_
HLA-E Ubiquitylation K208 -0.144 _SWTAVDTAAQISEQK(gl)SNDASEAEHQR_
HLA-E Ubiquitylation K238 -0.512 _GK(gl)ETLLHLEPPK_

Background Information for HLA-E:


Pubmed-HLA-E »
Uniprot-HLA-E »
Biogrid-HLA-E »
ProteomicsDB-HLA-E »

Tumorportal-HLA-E »
COSMIC-HLA-E »
GenomeRNAi-HLA-E »
Genecards-HLA-E


Protein-protein Interactions for HLA-E
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HLA-B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-G Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HLA-E
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ig-like_dom IPR007110 0.6
Category members MHC_I/II-like_Ag-recog IPR011162 0.02
Category members MHC_I_a_a1/a2 IPR001039 0
Category members Ig_C1-set IPR003597 0
Category members MHC_I_a_C IPR010579 0
Category members CD80_C2-set IPR013162 0
Category members MHC_I_a IPR027648 0


Protein complexes (CORUM database) featuring HLA-E
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HLA-E
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_894 KEGG_GRAFT_VERSUS_HOST_DISEASE 0 0.12
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members GO Category GO:0019882 antigen processing and presentation Database 0.03
Category members Pathway Pathway_446 KEGG_AUTOIMMUNE_THYROID_DISEASE 0 0
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_395 KEGG_TYPE_I_DIABETES_MELLITUS 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_905 KEGG_ALLOGRAFT_REJECTION 0 0
Category members GO Category GO:0001916 positive regulation of T cell mediated cytotoxicity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0042605 peptide antigen binding Database 0
Category members GO Category GO:0042612 MHC class I protein complex Database 0


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