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Query: HK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HK2 0 0.086 0.400 0.360 -0.317 0.133 -0.115

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HK2 Ubiquitylation K346 -0.340 _DISDIEGEK(gl)DGIRK_
HK2 Ubiquitylation K419 0.385 _STIGVDGSVYKK(gl)_
HK2 Ubiquitylation K451 -0.118 _SEDGSGK(gl)GAAMVTAVAYR_

Background Information for HK2:


Pubmed-HK2 »
Uniprot-HK2 »
Biogrid-HK2 »
ProteomicsDB-HK2 »

Tumorportal-HK2 »
COSMIC-HK2 »
GenomeRNAi-HK2 »
Genecards-HK2


Protein-protein Interactions for HK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HSP90AA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAD18 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOR1AIP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Hexokinase IPR001312 0.04
Category members Hexokinase_N IPR022672 0
Category members Hexokinase_C IPR022673 0


Protein complexes (CORUM database) featuring HK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0008645 hexose transport Database 4.15
Category members Pathway Pathway_98 REACTOME_GLUCOSE_TRANSPORT 0 3.58
Category members GO Category GO:0006096 glycolysis Database 2.49
Category members GO Category GO:0015758 glucose transport Database 2.09
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members Pathway Pathway_96 REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 0 0.23
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members Pathway Pathway_58 KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 0 0.1
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members Pathway Pathway_61 KEGG_AMINO_SUGAR_AND_NUCLEOTIDE_SUGAR_METABOLISM 0 0.04
Category members Pathway Pathway_64 KEGG_GALACTOSE_METABOLISM 0 0.04
Category members GO Category GO:0008637 apoptotic mitochondrial changes Database 0.01
Category members Pathway Pathway_60 KEGG_STARCH_AND_SUCROSE_METABOLISM 0 0
Category members Pathway Pathway_97 KEGG_TYPE_II_DIABETES_MELLITUS 0 0
Category members GO Category GO:0001678 cellular glucose homeostasis Database 0
Category members GO Category GO:0004340 glucokinase activity Database 0
Category members GO Category GO:0004396 hexokinase activity Database 0
Category members GO Category GO:0005536 glucose binding Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0008865 fructokinase activity Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0
Category members GO Category GO:0019158 mannokinase activity Database 0
Category members GO Category GO:0046324 regulation of glucose import Database 0
Category members GO Category GO:0046835 carbohydrate phosphorylation Database 0
Category members GO Category GO:0051156 glucose 6-phosphate metabolic process Database 0


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