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Query: HIST3H3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HIST3H3 0 1.335 -0.240 0.240
HIST3H3 0 1.335 -0.240 0.240 -0.118 0.659
HIST3H3 0 1.335 -0.240 0.240 -0.645

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HIST3H3 Ubiquitylation K80 -0.762 0.886 _EIAQDFK(gl)TDLR_
HIST3H3 Ubiquitylation K57 0.195 0.849 _YQK(gl)STELLIR_
HIST3H3 Ubiquitylation K123 -1.638 0.066 _VTIMPK(gl)DIQLAR_
HIST3H3 Ubiquitylation K37 -1.564 _SAPSTGGVK(gl)KPHR_
HIST3H3 Ubiquitylation K38 -1.512 _SAPSTGGVK(gl)KPHR_
HIST3H3 Ubiquitylation K37 -1.968 _SAPATGGVK(gl)KPHR_
HIST3H3 Ubiquitylation K38 -0.934 _SAPATGGVKK(gl)PHR_

Background Information for HIST3H3:


Pubmed-HIST3H3 »
Uniprot-HIST3H3 »
Biogrid-HIST3H3 »
ProteomicsDB-HIST3H3 »

Tumorportal-HIST3H3 »
COSMIC-HIST3H3 »
GenomeRNAi-HIST3H3 »
Genecards-HIST3H3


Protein-protein Interactions for HIST3H3
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in HIST3H3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Histone_core_D IPR007125 0.12
Category members Histone-fold IPR009072 0.01
Category members Histone_H3/CENP-A IPR000164 0


Protein complexes (CORUM database) featuring HIST3H3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HIST3H3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members Pathway Pathway_1312 REACTOME_PACKAGING_OF_TELOMERE_ENDS 0 4.09
Category members GO Category GO:0006334 nucleosome assembly Database 3.77
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members GO Category GO:0000786 nucleosome Database 2.41
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_889 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0 0.9
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Disease phenotype Autosomal_Recessive_Mental_Retardation Autosomal Recessive Mental Retardation Database 0


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