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Query: HIRA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HIRA 2 6.743 -1.620 2.740 0.660 0.537 0.081

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HIRA Phosphorylation T542 0.649 _DSM(ox)NAT(ph)STPAALSPSVLTTPSK_
HIRA Phosphorylation S661 2.076 0.577 _LMPVSLSVQS(ph)PAALTAEK_
HIRA Phosphorylation S549 0.985 0.496 _DSM(ox)NATSTPAALS(ph)PSVLTTPSK_

Background Information for HIRA:


Pubmed-HIRA »
Uniprot-HIRA »
Biogrid-HIRA »
ProteomicsDB-HIRA »

Tumorportal-HIRA »
COSMIC-HIRA »
GenomeRNAi-HIRA »
Genecards-HIRA


Protein-protein Interactions for HIRA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ASF1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASF1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MECP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TEAD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFAP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XAGE1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HIRA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52


Protein complexes (CORUM database) featuring HIRA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2235 ASF1-interacting protein complex Database 0


Categories featuring HIRA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members Disease phenotype 22q11.2_Deletion_Syndrome 22q11.2 Deletion Syndrome Database 0.31
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0016568 chromatin modification Database 0.18
Category members GO Category GO:0042692 muscle cell differentiation Database 0.1
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007369 gastrulation Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0


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