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Query: FAT1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FAT1 0 -1.698 -0.370 0.210

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FAT1 Ubiquitylation K313 -0.225 _SFPGSK(gl)EYK_
FAT1 Ubiquitylation K1542 -1.093 _DQDVPVK(gl)R_
FAT1 Ubiquitylation K4351 -1.682 -1.804 _KPLEEK(gl)PSQPYSAR_

Background Information for FAT1:


Pubmed-FAT1 »
Uniprot-FAT1 »
Biogrid-FAT1 »
ProteomicsDB-FAT1 »

Tumorportal-FAT1 »
COSMIC-FAT1 »
GenomeRNAi-FAT1 »
Genecards-FAT1


Protein-protein Interactions for FAT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CUL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait EZH2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NIPSNAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPIRE2 Cat. description Hein, Mann, Cell 2015
Category members IP bait C2orf48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKKL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM5C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GML Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IFNE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXPH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSG8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SIRT6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLAMF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XAGE1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FAT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members EGF-like_Ca-bd_dom IPR001881 0.69
Category members Cadherin IPR002126 0.32
Category members Cadherin-like IPR015919 0.21
Category members Laminin_G IPR001791 0.06
Category members ConA-like_lec_gl_sf IPR008985 0


Protein complexes (CORUM database) featuring FAT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FAT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0007163 establishment or maintenance of cell polarity Database 1.08
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0007156 homophilic cell adhesion Database 0.28
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members GO Category GO:0030175 filopodium Database 0.05
Category members Pathway Pathway_150 BIOCARTA_PPARA_PATHWAY 0 0.04
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0030054 cell junction Database 0


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