bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: ERCC8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ERCC8 2 4.718 -0.520 0.810 1.603 2.305

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for ERCC8:


Pubmed-ERCC8 »
Uniprot-ERCC8 »
Biogrid-ERCC8 »
ProteomicsDB-ERCC8 »

Tumorportal-ERCC8 »
COSMIC-ERCC8 »
GenomeRNAi-ERCC8 »
Genecards-ERCC8


Protein-protein Interactions for ERCC8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CUL4B Cat. description Hein, Mann, Cell 2015
Category members IP bait PFDN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ERCC8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12


Protein complexes (CORUM database) featuring ERCC8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 728 CSA-POLIIa complex Database 1.74
Category members Corum 727 CSA complex Database 1.33


Categories featuring ERCC8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_378 REACTOME_FORMATION_OF_TRANSCRIPTION_COUPLED_NER_TC_NER_REPAIR_COMPLEX 0 3.95
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members Disease phenotype UV-sensitive_syndrome UV-sensitive syndrome Database 0.82
Category members GO Category GO:0009411 response to UV Database 0.79
Category members Disease phenotype Cockayne_syndrome_type_2 Cockayne syndrome type 2 Database 0.54
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Disease phenotype Cockayne_syndrome_type_3 Cockayne syndrome type 3 Database 0.33
Category members GO Category GO:0010165 response to X-ray Database 0.32
Category members Disease phenotype Cockayne_syndrome_type_1 Cockayne syndrome type 1 Database 0.29
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0051865 protein autoubiquitination Database 0.18
Category members GO Category GO:0000109 nucleotide-excision repair complex Database 0.06
Category members GO Category GO:0045739 positive regulation of DNA repair Database 0.04
Category members GO Category GO:0031464 Cul4A-RING ubiquitin ligase complex Database 0.04
Category members GO Category GO:0006979 response to oxidative stress Database 0


.

© Copyright Svejstrup Laboratory 2015