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Query: EPS15

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EPS15 0 3.262 0.580 -0.640

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EPS15 Phosphorylation S324 1.499 1.080 _NIIGSS(ph)PVADFSAIK_
EPS15 Ubiquitylation K620 0.143 0.541 _SATSSSVSNVVITK(gl)NVFEETSVK_
EPS15 Phosphorylation S662 1.046 0.458 _SINKLDS(ph)PDPFK_
EPS15 Phosphorylation S108 -1.380 -0.251 _FHDTSS(ph)PLLISGTSAAELPWAVKPEDK_
EPS15 Phosphorylation S429 -0.224 -0.308 _S(ph)SPELLPSGVTDENEVTTAVTEK_
EPS15 Phosphorylation S428 -0.224 -0.557 _S(ph)SPELLPSGVTDENEVTTAVTEK_
EPS15 Phosphorylation S814 -0.764 -0.870 _LNDPFQPFPGNDS(ph)PKEKDPEIFCDPFTSATTTTNK_
EPS15 Ubiquitylation K654 -2.207 -1.253 _IGTPTRPCPLPPGK(gl)R_

Background Information for EPS15:


Pubmed-EPS15 »
Uniprot-EPS15 »
Biogrid-EPS15 »
ProteomicsDB-EPS15 »

Tumorportal-EPS15 »
COSMIC-EPS15 »
GenomeRNAi-EPS15 »
Genecards-EPS15


Protein-protein Interactions for EPS15
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PDLIM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PICALM Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC24C Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNPO Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C10orf96 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCHO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OXCT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PICALM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUNDC3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPC25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAMBPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EPS15
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-int_motif IPR003903 0.49
Category members EPS15_homology IPR000261 0
Category members EF_hand_dom IPR002048 0


Protein complexes (CORUM database) featuring EPS15
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 6036 PARK2-EPS15-EGFR Database 0.05
Category members Corum 3231 Eps15-stonin2 complex Database 0


Categories featuring EPS15
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_809 REACTOME_EGFR_DOWNREGULATION 0 1.1
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0016050 vesicle organization Database 0.31
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0030122 AP-2 adaptor complex Database 0.19
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_297 BIOCARTA_NDKDYNAMIN_PATHWAY 0 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0030136 clathrin-coated vesicle Database 0.06
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0032456 endocytic recycling Database 0
Category members GO Category GO:0048268 clathrin coat assembly Database 0
Category members GO Category GO:0060170 ciliary membrane Database 0


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