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Query: ELL

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ELL 0 -1.171 0.700 0.150 -0.733

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ELL Phosphorylation S308 -0.101 -0.337 _LCQPQSTGSLLGDPAAS(ph)SPPGER_
ELL Phosphorylation S309 -0.151 -0.339 _LCQPQSTGSLLGDPAASS(ph)PPGER_
ELL Phosphorylation S442 -0.565 -0.678 _LGLPLLTDCAQPSRPHGS(ph)PSR_
ELL Phosphorylation S437 -0.591 -0.813 _LGLPLLTDCAQPS(ph)RPHGSPSR_

Background Information for ELL:


Pubmed-ELL »
Uniprot-ELL »
Biogrid-ELL »
ProteomicsDB-ELL »

Tumorportal-ELL »
COSMIC-ELL »
GenomeRNAi-ELL »
Genecards-ELL


Protein-protein Interactions for ELL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AFF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASPM Cat. description Hein, Mann, Cell 2015
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ECT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HUWE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MLLT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait OFD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SIKE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VWA9 Cat. description Hein, Mann, Cell 2015
Category members IP bait AFF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMKV Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DENND2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EAF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ELL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ELL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RNA_pol_II_elong_fac_ELL IPR019464 0.04
Category members Occludin_RNApol2_elong_fac_ELL IPR010844 0


Protein complexes (CORUM database) featuring ELL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ELL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members Pathway Pathway_360 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 0 3.35
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members Pathway Pathway_363 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 0 1.84
Category members Pathway Pathway_367 REACTOME_ELONGATION_ARREST_AND_RECOVERY 0 1.67
Category members GO Category GO:0032786 positive regulation of DNA-dependent transcription, elongation Database 1.27
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0019902 phosphatase binding Database 0.16
Category members GO Category GO:0015030 Cajal body Database 0.04
Category members GO Category GO:0008023 transcription elongation factor complex Database 0
Category members GO Category GO:0010923 negative regulation of phosphatase activity Database 0


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