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Query: ELAVL1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ELAVL1 1 0.601 -0.160 0.190 -0.309 -1.620 -0.465 -0.437 0.244

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ELAVL1 Ubiquitylation K147 0.592 1.144 _TMTQK(gl)DVEDMFSR_
ELAVL1 Ubiquitylation K347 1.756 0.731 _ILQVSFK(gl)TNK_
ELAVL1 Phosphorylation S229 -1.194 -0.793 _NVALLSQLYHS(ph)PAR_
ELAVL1 Ubiquitylation K116 1.733 _LQSK(gl)TIK_
ELAVL1 Ubiquitylation K119 1.073 _TIK(gl)VSYAR_
ELAVL1 Ubiquitylation K131 -0.134 _PSSEVIK(gl)DANLYISGLPR_
ELAVL1 Phosphorylation S224 -1.255 _NVALLS(ph)QLYHSPARR_

Background Information for ELAVL1:


Pubmed-ELAVL1 »
Uniprot-ELAVL1 »
Biogrid-ELAVL1 »
ProteomicsDB-ELAVL1 »

Tumorportal-ELAVL1 »
COSMIC-ELAVL1 »
GenomeRNAi-ELAVL1 »
Genecards-ELAVL1


Protein-protein Interactions for ELAVL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ELAVL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA1 Cat. description Hein, Mann, Cell 2015


Protein Domains in ELAVL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RRM_dom IPR000504 4.34
Category members ELAD_HUD_SF IPR006548 0.05
Category members Hud_Sxl_RNA IPR002343 0.03


Protein complexes (CORUM database) featuring ELAVL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ELAVL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0017091 AU-rich element binding Database 0
Category members GO Category GO:0035925 mRNA 3'-UTR AU-rich region binding Database 0
Category members GO Category GO:0045727 positive regulation of translation Database 0
Category members GO Category GO:0048255 mRNA stabilization Database 0
Category members GO Category GO:0070935 3'-UTR-mediated mRNA stabilization Database 0


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