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Query: EIF4G3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF4G3 0 1.261 -0.870 0.650 -0.609 -0.700

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF4G3 Phosphorylation S436 1.117 _LVLS(ph)GEKK_
EIF4G3 Phosphorylation S1352 0.654 0.877 _GGS(ph)SKDLLDNQSQEEQR_
EIF4G3 Phosphorylation S1605 0.606 0.554 _LDFIESDS(ph)PCSSEALSK_
EIF4G3 Phosphorylation S691 -0.438 -0.303 _S(ph)PVPAQIAITVPK_
EIF4G3 Phosphorylation S428 -0.198 -0.408 _SPS(ph)PVLR_
EIF4G3 Phosphorylation S1353 0.803 -0.554 _GGS(ph)SKDLLDNQSQEEQRR_

Background Information for EIF4G3:


Pubmed-EIF4G3 »
Uniprot-EIF4G3 »
Biogrid-EIF4G3 »
ProteomicsDB-EIF4G3 »

Tumorportal-EIF4G3 »
COSMIC-EIF4G3 »
GenomeRNAi-EIF4G3 »
Genecards-EIF4G3


Protein-protein Interactions for EIF4G3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COMTD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPHA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM46A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KPTN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFATC2IP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNKD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QPRT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBFOX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDYHV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF4G3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members W2_domain IPR003307 0.04
Category members MIF4G-like_typ-3 IPR003890 0
Category members Initiation_fac_eIF4g_MI IPR003891 0


Protein complexes (CORUM database) featuring EIF4G3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EIF4G3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members Pathway Pathway_1274 BIOCARTA_EIF_PATHWAY 0 0.78
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0008135 translation factor activity, nucleic acid binding Database 0.53
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0016281 eukaryotic translation initiation factor 4F complex Database 0.08
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_638 BIOCARTA_EIF4_PATHWAY 0 0
Category members GO Category GO:0000339 RNA cap binding Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0045727 positive regulation of translation Database 0
Category members GO Category GO:0060903 positive regulation of meiosis I Database 0


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