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Query: EIF4A1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF4A1 0 1.279 1.010 -0.810 0.605 -1.090 0.048 0.029
EIF4A1 0 1.279 1.010 -0.810 0.248

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF4A1 Ubiquitylation K54 0.141 0.814 _GIYAYGFEK(gl)PSAIQQR_
EIF4A1 Ubiquitylation K381 -0.034 0.613 _K(gl)GVAINM(ox)VTEEDK(gl)R_
EIF4A1 Ubiquitylation K68 -0.187 0.201 _AILPCIK(gl)GYDVIAQAQSGTGK_
EIF4A1 Ubiquitylation K291 -0.226 _VDWLTEK(gl)MHAR_
EIF4A1 Ubiquitylation K174 -0.518 -0.258 _YLSPK(gl)YIK_
EIF4A1 Ubiquitylation K309 0.062 -0.357 _DFTVSAMHGDMDQK(gl)ERDVIMR_
EIF4A1 Ubiquitylation K369 0.625 -0.611 _K(gl)GVAINM(ox)VTEEDK(gl)R_
EIF4A1 Ubiquitylation K146 -1.101 -1.263 _AEVQK(gl)LQMEAPHIIVGTPGR_

Background Information for EIF4A1:


Pubmed-EIF4A1 »
Uniprot-EIF4A1 »
Biogrid-EIF4A1 »
ProteomicsDB-EIF4A1 »

Tumorportal-EIF4A1 »
COSMIC-EIF4A1 »
GenomeRNAi-EIF4A1 »
Genecards-EIF4A1


Protein-protein Interactions for EIF4A1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait IBTK Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3H Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3I Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4E Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF4A1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Helicase/UvrB_dom IPR006935 0.78
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members RNA_helicase_DEAD_Q_motif IPR014014 0.24


Protein complexes (CORUM database) featuring EIF4A1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5876 PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex Database 0.08
Category members Corum 5253 MNK1-eIF4F complex Database 0


Categories featuring EIF4A1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members Pathway Pathway_1274 BIOCARTA_EIF_PATHWAY 0 0.78
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0008135 translation factor activity, nucleic acid binding Database 0.53
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members GO Category GO:0016281 eukaryotic translation initiation factor 4F complex Database 0.08
Category members GO Category GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening Database 0.06
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_638 BIOCARTA_EIF4_PATHWAY 0 0
Category members Pathway Pathway_841 REACTOME_DEADENYLATION_OF_MRNA 0 0
Category members GO Category GO:0000339 RNA cap binding Database 0


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