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Query: EGLN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EGLN1 0 -2.707 0.180 -0.270 -1.041

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EGLN1 Phosphorylation S12 -1.100 -0.639 _(ac)ANDSGGPGGPS(ph)PSER_
EGLN1 Phosphorylation S125 -1.027 -0.755 _AKPPADPAAAAS(ph)PCR_

Background Information for EGLN1:


Pubmed-EGLN1 »
Uniprot-EGLN1 »
Biogrid-EGLN1 »
ProteomicsDB-EGLN1 »

Tumorportal-EGLN1 »
COSMIC-EGLN1 »
GenomeRNAi-EGLN1 »
Genecards-EGLN1


Protein-protein Interactions for EGLN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBWD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait N6AMT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EGLN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_MYND IPR002893 0.06
Category members Oxoglu/Fe-dep_dioxygenase IPR005123 0
Category members Pro_4_hyd_alph IPR006620 0


Protein complexes (CORUM database) featuring EGLN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5276 HIF1A-OS9-EGLN1 complex Database 0


Categories featuring EGLN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members Pathway Pathway_753 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN 0 0.35
Category members GO Category GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia Database 0.32
Category members GO Category GO:0045765 regulation of angiogenesis Database 0.24
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity Database 0.13
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Database 0.05
Category members GO Category GO:0005506 iron ion binding Database 0.04
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_821 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_976 PID_HIF1A_PATHWAY 0 0
Category members Disease phenotype Autosomal_dominant_secondary_polycythemia Autosomal dominant secondary polycythemia Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors Database 0
Category members GO Category GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline Database 0
Category members GO Category GO:0030821 negative regulation of cAMP catabolic process Database 0
Category members GO Category GO:0031418 L-ascorbic acid binding Database 0
Category members GO Category GO:0032364 oxygen homeostasis Database 0
Category members GO Category GO:0055008 cardiac muscle tissue morphogenesis Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0060347 heart trabecula formation Database 0
Category members GO Category GO:0060412 ventricular septum morphogenesis Database 0
Category members GO Category GO:0060711 labyrinthine layer development Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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