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Query: EDEM3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EDEM3 0 1.013 -0.320 0.890

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EDEM3 Ubiquitylation K447 0.123 _VPCGFAAMK(gl)DVR_
EDEM3 Ubiquitylation K435 -1.055 _TLIENLNK(gl)YAR_

Background Information for EDEM3:


Pubmed-EDEM3 »
Uniprot-EDEM3 »
Biogrid-EDEM3 »
ProteomicsDB-EDEM3 »

Tumorportal-EDEM3 »
COSMIC-EDEM3 »
GenomeRNAi-EDEM3 »
Genecards-EDEM3


Protein-protein Interactions for EDEM3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LRPPRC Cat. description Hein, Mann, Cell 2015
Category members IP bait ALOXE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ANGPTL7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OS9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EDEM3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Glyco_hydro_47 IPR001382 0.04
Category members Protease-assoc_domain IPR003137 0


Protein complexes (CORUM database) featuring EDEM3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring EDEM3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0006986 response to unfolded protein Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity Database 0.06
Category members Pathway Pathway_464 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE 0 0
Category members Pathway Pathway_465 REACTOME_CALNEXIN_CALRETICULIN_CYCLE 0 0
Category members Pathway Pathway_94 REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 0 0
Category members Pathway Pathway_95 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION 0 0
Category members GO Category GO:0004190 aspartic-type endopeptidase activity Database 0
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0006516 glycoprotein catabolic process Database 0
Category members GO Category GO:0018279 protein N-linked glycosylation via asparagine Database 0
Category members GO Category GO:0043687 post-translational protein modification Database 0


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