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Query: DNM1L

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DNM1L 0 -1.326 0.850 0.090 0.362

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DNM1L Phosphorylation S610 0.467 _VPSALAPAS(ph)QEPSPAASAEADGK_
DNM1L Ubiquitylation K371 -0.203 _DCLPELK(gl)TR_
DNM1L Phosphorylation S671 -1.151 -1.028 _SKPIPIM(ox)PAS(ph)PQK_
DNM1L Phosphorylation S614 -1.241 _VPSALAPASQEPS(ph)PAASAEADGK_
DNM1L Ubiquitylation K226 -0.801 _VPVGDQPK(gl)DIELQIR_

Background Information for DNM1L:


Pubmed-DNM1L »
Uniprot-DNM1L »
Biogrid-DNM1L »
ProteomicsDB-DNM1L »

Tumorportal-DNM1L »
COSMIC-DNM1L »
GenomeRNAi-DNM1L »
Genecards-DNM1L


Protein-protein Interactions for DNM1L
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDCA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF19 Cat. description Hein, Mann, Cell 2015
Category members IP bait LLGL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPIA Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait C14orf104 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CA14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DGUOK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DUSP23 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUFIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DNM1L
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Dynamin_GTPase IPR001401 0.36
Category members Dynamin_central IPR000375 0.33
Category members GED IPR003130 0.33
Category members Dynamin_SF IPR022812 0.11


Protein complexes (CORUM database) featuring DNM1L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 4200 DLP1-hFIS1 complex Database 0


Categories featuring DNM1L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006921 cellular component disassembly involved in execution phase of apoptosis Database 2.98
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_876 REACTOME_APOPTOTIC_EXECUTION_PHASE 0 2.5
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0030672 synaptic vesicle membrane Database 1.16
Category members GO Category GO:0061025 membrane fusion Database 0.93
Category members GO Category GO:0016559 peroxisome fission Database 0.54
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0051289 protein homotetramerization Database 0.44
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members GO Category GO:0010821 regulation of mitochondrion organization Database 0.04
Category members GO Category GO:0000266 mitochondrial fission Database 0
Category members GO Category GO:0005777 peroxisome Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043653 mitochondrial fragmentation involved in apoptotic process Database 0
Category members GO Category GO:0050714 positive regulation of protein secretion Database 0
Category members GO Category GO:0070266 necroptotic process Database 0
Category members GO Category GO:0070584 mitochondrion morphogenesis Database 0


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