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Query: DNER

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DNER 0 -0.927 -0.450 -0.080

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DNER Ubiquitylation K733 -0.847 _PLVTLIK(gl)_

Background Information for DNER:


Pubmed-DNER »
Uniprot-DNER »
Biogrid-DNER »
ProteomicsDB-DNER »

Tumorportal-DNER »
COSMIC-DNER »
GenomeRNAi-DNER »
Genecards-DNER


Protein-protein Interactions for DNER
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in DNER
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members EGF-like_Ca-bd_dom IPR001881 0.69
Category members EGF_extracell IPR013111 0.46


Protein complexes (CORUM database) featuring DNER
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring DNER
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0030425 dendrite Database 0.26
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0004888 transmembrane signaling receptor activity Database 0.15
Category members GO Category GO:0005112 Notch binding Database 0.14
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members GO Category GO:0001764 neuron migration Database 0
Category members GO Category GO:0007220 Notch receptor processing Database 0
Category members GO Category GO:0007416 synapse assembly Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0010001 glial cell differentiation Database 0
Category members GO Category GO:0030276 clathrin binding Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0048741 skeletal muscle fiber development Database 0


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