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Query: DDB1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DDB1 3 10.761 -1.620 2.560 0.925 1.008 1.640 0.761 0.768

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DDB1 Ubiquitylation K1121 -0.339 1.343 _M(ox)QEVVANLQYDDGSGM(ox)K(gl)R_
DDB1 Ubiquitylation K191 0.416 _HVK(gl)TYEVSLR_
DDB1 Ubiquitylation K383 0.577 0.094 _QGQGQLVTCSGAFK(gl)EGSLR_
DDB1 Ubiquitylation K857 0.452 -0.214 _IVVFQYSDGK(gl)LQTVAEK_
DDB1 Ubiquitylation K150 -0.646 _VIPLDRDNK(gl)ELK_
DDB1 Ubiquitylation K204 1.756 _EFNK(gl)GPWK_
DDB1 Ubiquitylation K484 -0.381 _LVSQEPK(gl)ALVSEWKEPQAK_

Background Information for DDB1:


Pubmed-DDB1 »
Uniprot-DDB1 »
Biogrid-DDB1 »
ProteomicsDB-DDB1 »

Tumorportal-DDB1 »
COSMIC-DDB1 »
GenomeRNAi-DDB1 »
Genecards-DDB1


Protein-protein Interactions for DDB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BRWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAMKK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CNOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL4B Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DTL Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DET1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRPC4AP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDTC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DDB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cleavage/polyA-sp_fac_asu_C IPR004871 0.34
Category members Quinoprot_gluc/sorb_DH IPR011041 0


Protein complexes (CORUM database) featuring DDB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1335 SNW1 complex Database 3.59
Category members Corum 929 CEN complex Database 3.25
Category members Corum 728 CSA-POLIIa complex Database 1.74
Category members Corum 726 DDB2 complex Database 1.33
Category members Corum 727 CSA complex Database 1.33
Category members Corum 1162 Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) Database 0.91
Category members Corum 790 DDB complex Database 0.33
Category members Corum 2722 Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) Database 0.14
Category members Corum 391 Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) Database 0.14
Category members Corum 1211 Ubiquitin E3 ligase (AHR, ARNT, DDB1, TBL3, CUL4B, RBX1) Database 0.05
Category members Corum 1214 Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) Database 0.04
Category members Corum 2172 Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1) Database 0.04


Categories featuring DDB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_857 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 0 4.24
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0031465 Cul4B-RING ubiquitin ligase complex Database 0.04
Category members GO Category GO:0031464 Cul4A-RING ubiquitin ligase complex Database 0.04


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