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Query: CUL7

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CUL7 0 -0.422 1.580 -1.240 -1.778 -0.501 -0.333 -0.058 0.103

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CUL7 Ubiquitylation K651 1.265 0.880 _DLINCHVYKK(gl)_

Background Information for CUL7:


Pubmed-CUL7 »
Uniprot-CUL7 »
Biogrid-CUL7 »
ProteomicsDB-CUL7 »

Tumorportal-CUL7 »
COSMIC-CUL7 »
GenomeRNAi-CUL7 »
Genecards-CUL7


Protein-protein Interactions for CUL7
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APEX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CASQ2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CETN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLMN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS3BP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPK14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TP53 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VTN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFC3H1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF263 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF408 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF669 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CUL7
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Cullin_homology IPR016158 1.15
Category members Cullin_N IPR001373 0.9
Category members Cullin_neddylation_domain IPR019559 0.68
Category members CPH_domain IPR021097 0.13
Category members APC_su10/DOC_dom IPR004939 0
Category members Galactose-bd-like IPR008979 0


Protein complexes (CORUM database) featuring CUL7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 81 Ubiquitin E3 ligase (SKP1A, FBXW8, CUL7, RBX1) Database 0.1


Categories featuring CUL7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0031461 cullin-RING ubiquitin ligase complex Database 0.77
Category members GO Category GO:0005680 anaphase-promoting complex Database 0.63
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0050775 positive regulation of dendrite morphogenesis Database 0.15
Category members GO Category GO:0007030 Golgi organization Database 0.13
Category members Pathway Pathway_148 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S 0 0.11
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members Disease phenotype 3M_syndrome 3M syndrome Database 0
Category members GO Category GO:0001570 vasculogenesis Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0031467 Cul7-RING ubiquitin ligase complex Database 0


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