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Query: CUL4A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CUL4A 2 9.698 -0.750 1.080 0.255 2.640 2.785 0.765 0.477

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CUL4A Phosphorylation S10 0.480 0.526 _KGS(ph)FSALVGR_
CUL4A Ubiquitylation K8 0.690 _K(gl)GSFSALVGR_
CUL4A Ubiquitylation K104 0.192 _VSPMLYK(gl)QLR_

Background Information for CUL4A:


Pubmed-CUL4A »
Uniprot-CUL4A »
Biogrid-CUL4A »
ProteomicsDB-CUL4A »

Tumorportal-CUL4A »
COSMIC-CUL4A »
GenomeRNAi-CUL4A »
Genecards-CUL4A


Protein-protein Interactions for CUL4A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BRWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHAF1A Cat. description Hein, Mann, Cell 2015
Category members IP bait COPS7A Cat. description Hein, Mann, Cell 2015
Category members IP bait CUL4A Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DDB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DTL Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM8A Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP6V0D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS7B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRBN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRYBA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF4L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF4L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DET1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLMN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMCO3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRPC4AP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDTC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CUL4A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cullin_homology IPR016158 1.15
Category members Cullin_N IPR001373 0.9
Category members Cullin_neddylation_domain IPR019559 0.68
Category members Cullin_repeat-like_dom IPR016159 0.66


Protein complexes (CORUM database) featuring CUL4A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 929 CEN complex Database 3.25
Category members Corum 728 CSA-POLIIa complex Database 1.74
Category members Corum 726 DDB2 complex Database 1.33
Category members Corum 727 CSA complex Database 1.33
Category members Corum 1162 Ubiquitin E3 ligase (DDB1, DDB2, CUL4A, CUL4B, RBX1) Database 0.91
Category members Corum 2171 Ubiquitin E3 ligase (CHEK1, CUL4A) Database 0.34
Category members Corum 2722 Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) Database 0.14
Category members Corum 391 Ubiquitin E3 ligase (DDB1, CUL4A, RBX1) Database 0.14
Category members Corum 223 CAND1-CUL4A-RBX1 complex Database 0.06
Category members Corum 1214 Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) Database 0.04
Category members Corum 2172 Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1) Database 0.04


Categories featuring CUL4A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0031461 cullin-RING ubiquitin ligase complex Database 0.77
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0031464 Cul4A-RING ubiquitin ligase complex Database 0.04
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007346 regulation of mitotic cell cycle Database 0
Category members GO Category GO:0051246 regulation of protein metabolic process Database 0


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