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Query: CUL2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CUL2 1 5.679 -1.790 3.760
CUL2 1 5.679 -1.790 3.760 -0.293 0.044 0.860 -0.146 0.162

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CUL2 Ubiquitylation K401 0.064 -0.162 _ALTSVVNYREPK(gl)SVCK_
CUL2 Ubiquitylation K35 1.454 _VVDFDETWNK(gl)LLTTIK_
CUL2 Ubiquitylation K257 0.023 _QEASNLLQESNCSQYMEK(gl)VLGR_
CUL2 Ubiquitylation K423 -0.295 _SAK(gl)GMTENEVEDR_

Background Information for CUL2:


Pubmed-CUL2 »
Uniprot-CUL2 »
Biogrid-CUL2 »
ProteomicsDB-CUL2 »

Tumorportal-CUL2 »
COSMIC-CUL2 »
GenomeRNAi-CUL2 »
Genecards-CUL2


Protein-protein Interactions for CUL2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CEP152 Cat. description Hein, Mann, Cell 2015
Category members IP bait COPS7A Cat. description Hein, Mann, Cell 2015
Category members IP bait LRR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLAIN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPTLC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait AVP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C22orf41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLMN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKZF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OXT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRAME Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRAMEF17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PYCARD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RGS20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSGA10IP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VHL Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CUL2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cullin_homology IPR016158 1.15
Category members Cullin_N IPR001373 0.9
Category members Cullin_neddylation_domain IPR019559 0.68
Category members Cullin_repeat-like_dom IPR016159 0.66


Protein complexes (CORUM database) featuring CUL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2715 Ubiquitin E3 ligase (CSN1, CSN8, HRT1, SKP1, SKP2, CUL1, CUL2, CUL3) Database 0.61
Category members Corum 221 CAND1-CUL2-RBX1 complex Database 0.06
Category members Corum 205 Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) Database 0
Category members Corum 622 Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) Database 0


Categories featuring CUL2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0031461 cullin-RING ubiquitin ligase complex Database 0.77
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0030163 protein catabolic process Database 0.38
Category members Pathway Pathway_753 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN 0 0.35
Category members GO Category GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia Database 0.32
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_821 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_976 PID_HIF1A_PATHWAY 0 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0030891 VCB complex Database 0
Category members GO Category GO:0031462 Cul2-RING ubiquitin ligase complex Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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