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Query: COPA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
COPA 0 2.603 0.225 0.454 0.171 0.017 -0.104

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
COPA Phosphorylation S173 0.372 0.591 _NLS(ph)PGAVESDVR_
COPA Ubiquitylation K574 -0.649 0.517 _VK(gl)GNNVYCLDR_
COPA Ubiquitylation K280 0.440 _VWDMSK(gl)R_
COPA Ubiquitylation K598 0.427 _VLTIDPTEFK(gl)FK_
COPA Ubiquitylation K238 -0.248 0.174 _M(ox)NESK(gl)AWEVDTCR_
COPA Ubiquitylation K827 -0.512 0.105 _GFFEGTIASKGK(gl)_
COPA Ubiquitylation K350 -0.803 -0.295 _QLDFNSSK(gl)DVAVMQLR_
COPA Ubiquitylation K1082 -0.397 _ETLEQQK(gl)R_
COPA Ubiquitylation K441 -1.204 -0.477 _NLK(gl)NEITK_
COPA Ubiquitylation K988 -0.943 _NWK(gl)DAGLK_
COPA Ubiquitylation K1184 -0.952 -1.020 _GKPVEK(gl)CPLSGACYSPEFK_
COPA Ubiquitylation K993 0.298 -1.064 _DAGLK(gl)NGVPAVGLK_
COPA Ubiquitylation K411 -2.140 _DADSQNPDAPEGK(gl)R_
COPA Ubiquitylation K4 0.360 _MLTK(gl)FETK_
COPA Ubiquitylation K46 -0.135 _MCTLIDK(gl)FDEHDGPVR_
COPA Ubiquitylation K169 -0.613 _K(gl)KNLSPGAVESDVR_
COPA Ubiquitylation K170 -0.613 _K(gl)KNLSPGAVESDVR_
COPA Ubiquitylation K446 -1.464 _NLKNEITK(gl)K_
COPA Ubiquitylation K600 0.188 _VLTIDPTEFKFK(gl)_
COPA Ubiquitylation K721 -0.198 _MMK(gl)IAEIR_
COPA Ubiquitylation K825 -0.187 _GFFEGTIASK(gl)GK_

Background Information for COPA:


Pubmed-COPA »
Uniprot-COPA »
Biogrid-COPA »
ProteomicsDB-COPA »

Tumorportal-COPA »
COSMIC-COPA »
GenomeRNAi-COPA »
Genecards-COPA


Protein-protein Interactions for COPA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C20orf172;DSN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait COPA Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCSTN Cat. description Hein, Mann, Cell 2015
Category members IP bait SACM1L Cat. description Hein, Mann, Cell 2015
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait COPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in COPA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12
Category members Coatomer_WD-assoc_reg IPR006692 0


Protein complexes (CORUM database) featuring COPA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring COPA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_670 PID_ARF_3PATHWAY 0 3.15
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members Pathway Pathway_709 BIOCARTA_ARAP_PATHWAY 0 0.76
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0005179 hormone activity Database 0.19
Category members GO Category GO:0006890 retrograde vesicle-mediated transport, Golgi to ER Database 0.05
Category members Pathway Pathway_1272 REACTOME_COPI_MEDIATED_TRANSPORT 0 0
Category members GO Category GO:0030117 membrane coat Database 0
Category members GO Category GO:0030126 COPI vesicle coat Database 0
Category members GO Category GO:0030157 pancreatic juice secretion Database 0
Category members GO Category GO:0048205 COPI coating of Golgi vesicle Database 0


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