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Query: CLTCL1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CLTCL1 0 2.554 -1.030 1.030
CLTCL1 0 2.554 -1.030 1.030 -0.538 -0.243 -0.478 0.375 0.284

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CLTCL1 Ubiquitylation K86 0.631 _VIALKAGK(gl)_
CLTCL1 Ubiquitylation K619 -0.177 0.475 _AHIAQLCEK(gl)AGLLQR_
CLTCL1 Ubiquitylation K506 0.267 _IVLYAK(gl)K_
CLTCL1 Ubiquitylation K507 0.050 0.267 _IVLYAKK(gl)_
CLTCL1 Phosphorylation T394 -0.123 0.181 _GILRT(ph)PDTIRR_
CLTCL1 Ubiquitylation K742 0.005 0.082 _TGQIK(gl)EVER_
CLTCL1 Ubiquitylation K1443 -2.089 -0.019 _VK(gl)QLPLVKPYLR_
CLTCL1 Ubiquitylation K389 -1.051 -0.085 _VAANAPK(gl)GILR_
CLTCL1 Ubiquitylation K737 -0.435 -0.298 _YIQAACK(gl)TGQIK_
CLTCL1 Ubiquitylation K1118 -0.674 -0.765 _AQLQK(gl)GMVK_
CLTCL1 Ubiquitylation K1209 -0.791 _CYDEK(gl)MYDAAK_
CLTCL1 Ubiquitylation K851 -0.859 _GQFSTDELVAEVEK(gl)R_
CLTCL1 Ubiquitylation K1516 -0.990 _IAAYLFK(gl)GNNR_
CLTCL1 Ubiquitylation K941 -1.252 _VCNENSLFK(gl)SEAR_
CLTCL1 Ubiquitylation K1449 -1.977 _AGQLPLVK(gl)PYLR_
CLTCL1 Ubiquitylation K1449 -2.307 _QLPLVK(gl)PYLR_
CLTCL1 Ubiquitylation K83 0.714 _VIALK(gl)AGK_
CLTCL1 Ubiquitylation K911 -1.282 _YCEK(gl)RDPHLACVAYER_
CLTCL1 Ubiquitylation K1609 -0.714 _EYLTK(gl)VDKLDASESLR_

Background Information for CLTCL1:


Pubmed-CLTCL1 »
Uniprot-CLTCL1 »
Biogrid-CLTCL1 »
ProteomicsDB-CLTCL1 »

Tumorportal-CLTCL1 »
COSMIC-CLTCL1 »
GenomeRNAi-CLTCL1 »
Genecards-CLTCL1


Protein-protein Interactions for CLTCL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait PICALM Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC16A Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC24C Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C4orf6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC69 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCL21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLINT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTSL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CUTA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGFRL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GALNT7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLTSCR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNAI3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRIA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HSPBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PICALM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKAG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVRIG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC37A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAMBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAMBPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCP10L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM199 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTC30A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTC30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TTC9B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR5B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF169 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CLTCL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Clathrin_H-chain/VPS_repeat IPR000547 0
Category members Clathrin_H-chain_propeller_N IPR001473 0
Category members Clathrin_H-chain_linker_core IPR015348 0
Category members Clathrin_heavy_chain IPR016341 0
Category members Clathrin_H-chain_propeller_rpt IPR022365 0


Protein complexes (CORUM database) featuring CLTCL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CLTCL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005488 binding Database 9.32
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members Pathway Pathway_1268 REACTOME_GAP_JUNCTION_DEGRADATION 0 0.08
Category members GO Category GO:0030136 clathrin-coated vesicle Database 0.06
Category members Pathway Pathway_1267 REACTOME_GAP_JUNCTION_TRAFFICKING 0 0
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006898 receptor-mediated endocytosis Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0009653 anatomical structure morphogenesis Database 0
Category members GO Category GO:0030130 clathrin coat of trans-Golgi network vesicle Database 0
Category members GO Category GO:0030132 clathrin coat of coated pit Database 0
Category members GO Category GO:0030135 coated vesicle Database 0
Category members GO Category GO:0046326 positive regulation of glucose import Database 0


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