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Query: CDK5RAP2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDK5RAP2 0 3.755 -0.900 1.740 -0.181 0.284

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDK5RAP2 Phosphorylation S1074 1.217 0.953 _ENPEDVLS(ph)PTSVATYLSSK_
CDK5RAP2 Phosphorylation S1238 0.477 0.111 _DLS(ph)PPRYDSLVQSQAR_
CDK5RAP2 Phosphorylation S697 -0.007 _LAS(ph)T(ph)EQTELLASK_
CDK5RAP2 Phosphorylation T698 -0.007 _LAS(ph)T(ph)EQTELLASK_
CDK5RAP2 Ubiquitylation K943 -0.252 _SRLPILIK(gl)_
CDK5RAP2 Phosphorylation S1889 -0.312 _GNLELRPGGAHPGTCSPS(ph)RPGS_
CDK5RAP2 Phosphorylation S1350 -1.016 -0.606 _IEEDNLTYQHLLPES(ph)PEPSASHALSDYETSEK_
CDK5RAP2 Phosphorylation T1885 -0.869 _GNLELRPGGAHPGT(ph)CSPSRPGS_
CDK5RAP2 Phosphorylation S1887 -0.612 -1.053 _GNLELRPGGAHPGTCS(ph)PSRPGS_
CDK5RAP2 Ubiquitylation K489 -0.006 _HLTESTNQK(gl)DVLLQK_

Background Information for CDK5RAP2:


Pubmed-CDK5RAP2 »
Uniprot-CDK5RAP2 »
Biogrid-CDK5RAP2 »
ProteomicsDB-CDK5RAP2 »

Tumorportal-CDK5RAP2 »
COSMIC-CDK5RAP2 »
GenomeRNAi-CDK5RAP2 »
Genecards-CDK5RAP2


Protein-protein Interactions for CDK5RAP2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK5RAP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait DYNLL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNT Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKACB Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKAR2A Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKAR2B Cat. description Hein, Mann, Cell 2015
Category members IP bait USO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USP43 Cat. description Hein, Mann, Cell 2015
Category members IP bait C1orf87 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C4orf6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C6orf141 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CARD9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM81B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKBIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPXN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MLF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDE4DIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKACB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKAR2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RALBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDK5RAP2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Man6P_isomerase_rcpt-bd_dom IPR009011 0.25


Protein complexes (CORUM database) featuring CDK5RAP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CDK5RAP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0015631 tubulin binding Database 0.83
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0001578 microtubule bundle formation Database 0.49
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0000132 establishment of mitotic spindle orientation Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0022008 neurogenesis Database 0.16
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0046600 negative regulation of centriole replication Database 0.06
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members GO Category GO:0051297 centrosome organization Database 0.04
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Disease phenotype Autosomal_recessive_primary_microcephaly Autosomal recessive primary microcephaly Database 0
Category members GO Category GO:0000242 pericentriolar material Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0045664 regulation of neuron differentiation Database 0


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