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Query: CDC37

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDC37 0 4.568 -1.030 1.190 0.339 0.690 1.087

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDC37 Phosphorylation S5 0.600 0.297 _(ac)VDYS(ph)VWDHIEVSDDEDETHPNIDTASLFR_
CDC37 Phosphorylation S13 0.017 0.075 _(ac)VDYSVWDHIEVS(ph)DDEDETHPNIDTASLFR_
CDC37 Ubiquitylation K330 -0.426 0.035 _MDPTDAK(gl)YHMQR_
CDC37 Ubiquitylation K45 -0.075 _MEQFQK(gl)EKEELDR_
CDC37 Ubiquitylation K69 0.281 _LK(gl)ELEVAEGGK_
CDC37 Ubiquitylation K132 -0.873 _SMVNTK(gl)PEKTEEDSEEVR_
CDC37 Ubiquitylation K157 0.330 _TFVEKYEK(gl)QIK_
CDC37 Ubiquitylation K352 -1.772 _ASEAK(gl)EGEEAGPGDPLLEAVPK_

Background Information for CDC37:


Pubmed-CDC37 »
Uniprot-CDC37 »
Biogrid-CDC37 »
ProteomicsDB-CDC37 »

Tumorportal-CDC37 »
COSMIC-CDC37 »
GenomeRNAi-CDC37 »
Genecards-CDC37


Protein-protein Interactions for CDC37
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC37 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDCA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait FTSJ1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSP90AA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IKBKG Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait AKT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK11A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FYN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ITK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAP2K5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAP3K6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDIK1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSKH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STK35 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YES1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDC37
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cdc37_Hsp90-bd IPR013874 0


Protein complexes (CORUM database) featuring CDC37
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5266 TNF-alpha/NF-kappa B signaling complex 6 Database 3.74
Category members Corum 5199 Kinase maturation complex 1 Database 3.38
Category members Corum 5268 TNF-alpha/NF-kappa B signaling complex 7 Database 1.75
Category members Corum 5269 TNF-alpha/NF-kappa B signaling complex 8 Database 1.36
Category members Corum 5234 IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex Database 0.57
Category members Corum 2112 CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex Database 0.36
Category members Corum 5285 TNF-alpha/NF-kappa B signaling complex 9 Database 0.21
Category members Corum 5212 Kinase maturation complex 2 Database 0.18
Category members Corum 5286 TNF-alpha/NF-kappa B signaling complex 10 Database 0.18
Category members Corum 5849 HSP90-CDC37-LRRK2 complex Database 0.08
Category members Corum 5613 Emerin complex 25 Database 0.04


Categories featuring CDC37
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members GO Category GO:0051087 chaperone binding Database 1.69
Category members GO Category GO:0031072 heat shock protein binding Database 1.59
Category members Pathway Pathway_583 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR 0 0.68
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0006605 protein targeting Database 0.29
Category members GO Category GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity Database 0.13
Category members GO Category GO:0043422 protein kinase B binding Database 0.12
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0060334 regulation of interferon-gamma-mediated signaling pathway Database 0.07
Category members GO Category GO:0031435 mitogen-activated protein kinase kinase kinase binding Database 0
Category members GO Category GO:0051879 Hsp90 protein binding Database 0
Category members GO Category GO:0060338 regulation of type I interferon-mediated signaling pathway Database 0


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