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Query: CBFB

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CBFB 0 1.034 1.550 -0.600

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CBFB Ubiquitylation K28 0.486 0.548 _ECEIK(gl)YTGFR_

Background Information for CBFB:


Pubmed-CBFB »
Uniprot-CBFB »
Biogrid-CBFB »
ProteomicsDB-CBFB »

Tumorportal-CBFB »
COSMIC-CBFB »
GenomeRNAi-CBFB »
Genecards-CBFB


Protein-protein Interactions for CBFB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARL6IP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GCHFR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAS2R41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CBFB
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring CBFB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5770 RUNX1-CBF-beta-DNA complex Database 0


Categories featuring CBFB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0060216 definitive hemopoiesis Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Disease phenotype Acute_myeloid_leukemia_with_abnormal_bone_marrow_eosinophils_inv(16)(p13q22)_or_t(16;16)(p13;q22) Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) Database 0
Category members GO Category GO:0001503 ossification Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0005575 cellular_component Database 0
Category members GO Category GO:0030098 lymphocyte differentiation Database 0
Category members GO Category GO:0030099 myeloid cell differentiation Database 0
Category members GO Category GO:0048469 cell maturation Database 0


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