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Query: CANX

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CANX 0 0.937 0.090 -0.410 0.234 -0.021 -1.207 -0.098 -0.313

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CANX Ubiquitylation K268 1.422 _TYFTDK(gl)K_
CANX Ubiquitylation K494 -0.002 1.403 _IVDDWANDGWGLKK(gl)_
CANX Ubiquitylation K122 0.021 0.828 _GTLSGWILSK(gl)AK_
CANX Phosphorylation S589 0.479 0.421 _S(ph)DAEEDGGTVSQEEEDR_
CANX Phosphorylation S599 0.395 0.352 _SDAEEDGGTVS(ph)QEEEDR_
CANX Phosphorylation S618 0.442 0.320 _AEEDEILNRS(ph)PR_
CANX Phosphorylation T597 0.469 0.188 _SDAEEDGGT(ph)VSQEEEDRKPK_
CANX Ubiquitylation K96 -1.324 _VTYK(gl)APVPTGEVYFADSFDR_
CANX Ubiquitylation K124 -0.479 _GTLSGWILSKAK(gl)_
CANX Ubiquitylation K153 -0.762 _LPGDK(gl)GLVLMSR_
CANX Ubiquitylation K252 0.015 _TGIYEEK(gl)HAK_
CANX Ubiquitylation K415 -1.726 _CESAPGCGVWQRPVIDNPNYK(gl)GK_
CANX Ubiquitylation K417 -0.679 _PVIDNPNYKGK(gl)_

Background Information for CANX:


Pubmed-CANX »
Uniprot-CANX »
Biogrid-CANX »
ProteomicsDB-CANX »

Tumorportal-CANX »
COSMIC-CANX »
GenomeRNAi-CANX »
Genecards-CANX


Protein-protein Interactions for CANX
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATXN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait CHST15 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLU Cat. description Hein, Mann, Cell 2015
Category members IP bait GBA Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LNPEP Cat. description Hein, Mann, Cell 2015
Category members IP bait NCSTN Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKACB Cat. description Hein, Mann, Cell 2015
Category members IP bait RFWD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPIRE2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOR1AIP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait A4GALT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ADAM21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ADAM30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AGT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AMIGO3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARSG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait B3GNT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C12orf49 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C17orf101 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNJL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHST14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHST15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHST6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHST8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHST9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLEC2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNASE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPEP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM187B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM5B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FUCA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FUT9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GABRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GAL3ST1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GXYLT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HYAL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IGSF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL27RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MPPE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCEH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OPCML Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RX5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLTP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POGLUT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCNN1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SGK196 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMPD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST3GAL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST8SIA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMED6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS11B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TOR3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRHDE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UST Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WNT16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WNT3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WNT7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CANX
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Calret/calnex IPR001580 0
Category members ConA-like_lec_gl_sf IPR008985 0
Category members Calreticulin/calnexin_P_dom IPR009033 0


Protein complexes (CORUM database) featuring CANX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CANX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005840 ribosome Database 12.2
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0006457 protein folding Database 4.93
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members Pathway Pathway_766 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC 0 0.47
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members GO Category GO:0048488 synaptic vesicle endocytosis Database 0.05
Category members GO Category GO:0009306 protein secretion Database 0.02
Category members Pathway Pathway_464 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE 0 0
Category members Pathway Pathway_465 REACTOME_CALNEXIN_CALRETICULIN_CYCLE 0 0
Category members Pathway Pathway_94 REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 0 0
Category members Pathway Pathway_95 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION 0 0
Category members GO Category GO:0001948 glycoprotein binding Database 0
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0018279 protein N-linked glycosylation via asparagine Database 0
Category members GO Category GO:0032839 dendrite cytoplasm Database 0
Category members GO Category GO:0034185 apolipoprotein binding Database 0
Category members GO Category GO:0035255 ionotropic glutamate receptor binding Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043687 post-translational protein modification Database 0
Category members GO Category GO:0061077 chaperone-mediated protein folding Database 0


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