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Query: BAP1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BAP1 0 0.011 -0.249

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BAP1 Phosphorylation S292 0.575 _SASNKS(ph)PLVLEANR_
BAP1 Phosphorylation S520 0.193 _SANPTRPS(ph)SPVTSHISK_
BAP1 Phosphorylation T517 -0.361 _SANPT(ph)RPSSPVTSHISK_
BAP1 Phosphorylation S521 -0.315 -0.535 _SANPTRPSS(ph)PVTSHISK_
BAP1 Phosphorylation S325 -0.806 -0.868 _APAASEGNHTDGAEEAAGSCAQAPS(ph)HSPPNKPK_
BAP1 Phosphorylation S327 -1.164 _APAASEGNHTDGAEEAAGSCAQAPSHS(ph)PPNKPK_

Background Information for BAP1:


Pubmed-BAP1 »
Uniprot-BAP1 »
Biogrid-BAP1 »
ProteomicsDB-BAP1 »

Tumorportal-BAP1 »
COSMIC-BAP1 »
GenomeRNAi-BAP1 »
Genecards-BAP1


Protein-protein Interactions for BAP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ENTHD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KDM1B Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1107 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEPT6 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMS Cat. description Hein, Mann, Cell 2015
Category members IP bait TSNAX Cat. description Hein, Mann, Cell 2015
Category members IP bait VBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASXL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMK2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GOPC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSME3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BAP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_C12_UCH IPR001578 0.35


Protein complexes (CORUM database) featuring BAP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring BAP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0004843 ubiquitin-specific protease activity Database 3.28
Category members GO Category GO:0004221 ubiquitin thiolesterase activity Database 1.36
Category members GO Category GO:0016579 protein deubiquitination Database 1.32
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0071108 protein K48-linked deubiquitination Database 0.88
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Disease phenotype MESOTHELIOMA_MALIGNANT MESOTHELIOMA MALIGNANT Database 0.31
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0035522 monoubiquitinated histone H2A deubiquitination Database 0.05
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members GO Category GO:0001558 regulation of cell growth Database 0
Category members GO Category GO:0006464 cellular protein modification process Database 0


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