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Query: APC2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
APC2 0 1.850 0.850 -0.820 0.008 0.065

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
APC2 Phosphorylation S1046 0.412 1.084 _YSDEQLNSGRQSPS(ph)QNER_
APC2 Phosphorylation S2571 0.693 0.817 _TGS(ph)SSSILSASSESSEK_
APC2 Phosphorylation S2673 0.326 0.501 _S(ph)GRSPTGNTPPVIDSVSEK_
APC2 Phosphorylation S1044 0.097 0.452 _YSDEQLNSGRQS(ph)PSQNER_
APC2 Phosphorylation S2095 0.363 _DIQRPDSEHGLS(ph)PDSENFDWK_
APC2 Phosphorylation S1362 -0.007 0.328 _AVEFSSGAKS(ph)PSK_
APC2 Phosphorylation S749 0.276 _YKDANIM(ox)SPGS(ph)SLPSLHVR_
APC2 Phosphorylation S2262 -0.026 0.240 _TPASKS(ph)PSEGQTATTSPR_
APC2 Phosphorylation S746 0.284 0.140 _DANIMS(ph)PGSSLPSLHVR_
APC2 Phosphorylation T2678 -0.028 0.136 _SPT(ph)GNTPPVIDSVSEK_
APC2 Phosphorylation T1775 0.099 _KPT(ph)SPVKPIPQNTEYR_
APC2 Phosphorylation S1776 0.019 0.099 _KPTS(ph)PVKPIPQNTEYR_
APC2 Phosphorylation S2676 -0.478 0.096 _SGRS(ph)PTGNTPPVIDSVSEK_
APC2 Phosphorylation S2127 -0.031 _AIQEGANSIVSSLHQAAAAACLS(ph)R_
APC2 Phosphorylation S2451 -0.249 -0.285 _EAPS(ph)PTLR_
APC2 Phosphorylation S782 -0.471 -0.446 _ALEAELDAQHLSETFDNIDNLS(ph)PK_
APC2 Phosphorylation S2537 -0.505 _SHSES(ph)PSRLPINR_
APC2 Phosphorylation T1440 -1.261 -0.875 _SKT(ph)PPPPPQTAQTK_
APC2 Phosphorylation S2260 -0.624 _TPAS(ph)KSPSEGQTATTSPR_

Background Information for APC2:


Pubmed-APC2 »
Uniprot-APC2 »
Biogrid-APC2 »
ProteomicsDB-APC2 »

Tumorportal-APC2 »
COSMIC-APC2 »
GenomeRNAi-APC2 »
Genecards-APC2


Protein-protein Interactions for APC2
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in APC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Armadillo IPR000225 1.58
Category members Prefoldin IPR009053 0
Category members APC_dom IPR026831 0


Protein complexes (CORUM database) featuring APC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring APC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0031258 lamellipodium membrane Database 0.15
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0005884 actin filament Database 0.08
Category members GO Category GO:0005881 cytoplasmic microtubule Database 0.04
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0016342 catenin complex Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0035414 negative regulation of catenin import into nucleus Database 0


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