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Query: ANXA2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ANXA2 0 4.535 -1.230 1.610
ANXA2 0 4.535 -1.230 1.610 -0.075 0.002 -0.652 0.608 0.330
ANXA2 0 4.535 -0.830 1.020
ANXA2 0 4.535 -0.830 1.020 -0.075 0.002 -0.652 0.608 0.330
ANXA2 0 4.535 -0.740 0.850
ANXA2 0 4.535 -0.740 0.850 -0.075 0.002 -0.652 0.608 0.330

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ANXA2 Ubiquitylation K204 0.375 1.026 _DLYDAGVK(gl)R_
ANXA2 Ubiquitylation K148 0.314 1.024 _VYK(gl)EMYK_
ANXA2 Ubiquitylation K176 -0.855 0.760 _LMVALAK(gl)GR_
ANXA2 Ubiquitylation K324 0.768 0.350 _SLYYYIQQDTK(gl)GDYQK_
ANXA2 Phosphorylation S12 0.179 _(ac)STVHEILCKLS(ph)LEGDHSTPPSAYGSVK_
ANXA2 Phosphorylation T19 0.015 -0.422 _LSLEGDHST(ph)PPSAYGSVK_
ANXA2 Phosphorylation S26 -0.518 -0.691 _LSLEGDHSTPPSAYGS(ph)VK_
ANXA2 Phosphorylation S22 -0.273 -1.050 _LSLEGDHSTPPS(ph)AYGSVK_
ANXA2 Phosphorylation Y24 -1.100 _LSLEGDHSTPPSAY(ph)GSVK_
ANXA2 Ubiquitylation K49 0.729 _TK(gl)GVDEVTIVNILTNR_
ANXA2 Ubiquitylation K206 -0.599 _DLYDAGVK(gl)RK_
ANXA2 Ubiquitylation K302 0.390 _SEVDMLK(gl)IR_

Background Information for ANXA2:


Pubmed-ANXA2 »
Uniprot-ANXA2 »
Biogrid-ANXA2 »
ProteomicsDB-ANXA2 »

Tumorportal-ANXA2 »
COSMIC-ANXA2 »
GenomeRNAi-ANXA2 »
Genecards-ANXA2


Protein-protein Interactions for ANXA2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANXA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ANXA2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members AnnexinV IPR002392 0.78
Category members Annexin IPR001464 0.13
Category members Annexin_repeat IPR018502 0.13


Protein complexes (CORUM database) featuring ANXA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ANXA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members GO Category GO:0070062 extracellular vesicular exosome Database 1.36
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0008092 cytoskeletal protein binding Database 0.5
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0042383 sarcolemma Database 0.36
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0044354 macropinosome Database 0.25
Category members GO Category GO:0004859 phospholipase inhibitor activity Database 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0043220 Schmidt-Lanterman incisure Database 0.21
Category members GO Category GO:0035749 myelin sheath adaxonal region Database 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0005546 phosphatidylinositol-4,5-bisphosphate binding Database 0.09
Category members GO Category GO:0048146 positive regulation of fibroblast proliferation Database 0.05
Category members GO Category GO:0071229 cellular response to acid Database 0.04
Category members GO Category GO:0019897 extrinsic to plasma membrane Database 0.03
Category members GO Category GO:0031982 vesicle Database 0.01
Category members GO Category GO:0030199 collagen fibril organization Database 0.01
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0005544 calcium-dependent phospholipid binding Database 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0005811 lipid particle Database 0
Category members GO Category GO:0007589 body fluid secretion Database 0
Category members GO Category GO:0017137 Rab GTPase binding Database 0
Category members GO Category GO:0031340 positive regulation of vesicle fusion Database 0
Category members GO Category GO:0042730 fibrinolysis Database 0
Category members GO Category GO:0051099 positive regulation of binding Database 0


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