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Query: ADAR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ADAR 1 4.748 -0.700 1.260 0.674 -0.016
ADAR 1 4.748 -0.700 1.260 -0.595 -2.524 -1.253 -1.530 -0.195

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ADAR Phosphorylation T644 2.146 1.082 _TAESQT(ph)PTPSATSFFSGK_
ADAR Ubiquitylation K1158 1.002 0.569 _VSIYDSK(gl)R_
ADAR Phosphorylation S866 0.195 _TMLLLS(ph)RSPEAQPK_
ADAR Phosphorylation S657 0.046 _S(ph)PVTTLLECMHK_
ADAR Ubiquitylation K427 -0.338 _NTNSVPETAPAAIPETK(gl)R_
ADAR Ubiquitylation K680 -0.527 _LLSK(gl)EGPAHEPK_
ADAR Ubiquitylation K841 1.158 _VLIGENEK(gl)AER_
ADAR Ubiquitylation K987 -0.367 _DSIFEPAK(gl)GGEK_
ADAR Ubiquitylation K991 -0.367 _DSIFEPAK(gl)GGEK_

Background Information for ADAR:


Pubmed-ADAR »
Uniprot-ADAR »
Biogrid-ADAR »
ProteomicsDB-ADAR »

Tumorportal-ADAR »
COSMIC-ADAR »
GenomeRNAi-ADAR »
Genecards-ADAR


Protein-protein Interactions for ADAR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EXOSC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait FUS Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MMGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYC Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SESN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TACC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZFC3H1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USP38 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ADAR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members dsRNA_A_deaminase IPR000607 0.24
Category members dsRNA-bd_dom IPR014720 0.23
Category members A_deamin IPR002466 0


Protein complexes (CORUM database) featuring ADAR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3102 DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex Database 0.44
Category members Corum 906 ADAR1-CDK2 complex Database 0


Categories featuring ADAR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Disease phenotype Familial_infantile_bilateral_striatal_necrosis Familial infantile bilateral striatal necrosis Database 0.32
Category members GO Category GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation Database 0.18
Category members GO Category GO:0006396 RNA processing Database 0.17
Category members GO Category GO:0044530 supraspliceosomal complex Database 0.08
Category members GO Category GO:0035455 response to interferon-alpha Database 0.08
Category members GO Category GO:0003726 double-stranded RNA adenosine deaminase activity Database 0.07
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Disease phenotype Aicardi-Goutieres_Syndrome Aicardi-Goutieres Syndrome Database 0.05
Category members GO Category GO:0045070 positive regulation of viral genome replication Database 0.04
Category members Pathway Pathway_354 KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 0 0
Category members Pathway Pathway_913 REACTOME_INTERFERON_ALPHA_BETA_SIGNALING 0 0
Category members GO Category GO:0004000 adenosine deaminase activity Database 0
Category members GO Category GO:0006382 adenosine to inosine editing Database 0
Category members GO Category GO:0006611 protein export from nucleus Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0016553 base conversion or substitution editing Database 0
Category members GO Category GO:0016556 mRNA modification Database 0
Category members GO Category GO:0031047 gene silencing by RNA Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0060337 type I interferon signaling pathway Database 0


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