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Query: AARS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AARS 2 11.740 -0.590 1.990 1.091
AARS 2 11.740 -0.590 1.990 0.992

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AARS Ubiquitylation K820 2.550 4.438 _DELRETLK(gl)SLK_
AARS Ubiquitylation K338 0.835 _YAHEK(gl)LNASR_
AARS Ubiquitylation K650 0.052 0.332 _GAMSTQQIK(gl)K_
AARS Phosphorylation S563 0.468 0.212 _VDDSS(ph)EDKTEFTVK_
AARS Ubiquitylation K762 -0.271 0.079 _IVAVTGAEAQK(gl)ALR_
AARS Ubiquitylation K677 0.025 _AVYTQDCPLAAAK(gl)AIQGLR_
AARS Ubiquitylation K625 -0.494 -0.399 _SVLGEADQK(gl)GSLVAPDR_

Background Information for AARS:


Pubmed-AARS »
Uniprot-AARS »
Biogrid-AARS »
ProteomicsDB-AARS »

Tumorportal-AARS »
COSMIC-AARS »
GenomeRNAi-AARS »
Genecards-AARS


Protein-protein Interactions for AARS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015


Protein Domains in AARS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ala-tRNA-synth_IIc_N IPR018164 0.29
Category members Ala-tRNA-synth_IIc_core IPR018165 0.29
Category members tRNA_SAD IPR012947 0.23
Category members Ala-tRNA-lgiase_IIc IPR002318 0.18
Category members Ala-tRNA-ligase_IIc_anticod-bd IPR018162 0.18
Category members Thr/Ala-tRNA-synth_IIc_edit IPR018163 0.08


Protein complexes (CORUM database) featuring AARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring AARS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006457 protein folding Database 4.93
Category members Pathway Pathway_201 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION 0 3.57
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members Pathway Pathway_202 REACTOME_TRNA_AMINOACYLATION 0 1.34
Category members GO Category GO:0006418 tRNA aminoacylation for protein translation Database 0.91
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members Pathway Pathway_409 KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 0.82
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0021680 cerebellar Purkinje cell layer development Database 0.44
Category members GO Category GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds Database 0.42
Category members GO Category GO:0008033 tRNA processing Database 0.39
Category members GO Category GO:0004813 alanine-tRNA ligase activity Database 0.29
Category members GO Category GO:0006419 alanyl-tRNA aminoacylation Database 0.29
Category members GO Category GO:0006400 tRNA modification Database 0.25
Category members GO Category GO:0002161 aminoacyl-tRNA editing activity Database 0.23
Category members GO Category GO:0016597 amino acid binding Database 0.11
Category members GO Category GO:0006450 regulation of translational fidelity Database 0.04
Category members GO Category GO:0050885 neuromuscular process controlling balance Database 0.02
Category members GO Category GO:0000049 tRNA binding Database 0
Category members GO Category GO:0001942 hair follicle development Database 0
Category members GO Category GO:0034620 cellular response to unfolded protein Database 0
Category members GO Category GO:0043039 tRNA aminoacylation Database 0
Category members GO Category GO:0043200 response to amino acid Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050905 neuromuscular process Database 0


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