bioLOGIC-db

bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

Query: ZRANB3

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
W

[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
ZRANB3	0	0.295	-0.760	1.140

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
ZRANB3	Ubiquitylation	K163		-0.845	_VVIVDESHYMK(gl)SR_
ZRANB3	Ubiquitylation	K179		-1.035	_ILLPIVQK(gl)AR_

Background Information for ZRANB3:

Pubmed-ZRANB3 »

Uniprot-ZRANB3 »

Biogrid-ZRANB3 »

ProteomicsDB-ZRANB3 »

Tumorportal-ZRANB3 »

COSMIC-ZRANB3 »

GenomeRNAi-ZRANB3 »

Genecards-ZRANB3

Protein-protein Interactions for ZRANB3

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait CAMK2D	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait CD79B	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait IMPDH1	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait ISLR	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait LAMP3	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait TPCN2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in ZRANB3

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	SNF2_N	IPR000330	3.38
Category members	P-loop_NTPase	IPR027417	2.83
Category members	Helicase_C	IPR001650	2.48
Category members	Helicase_ATP-bd	IPR014001	2.48
Category members	Helicase/UvrB_dom	IPR006935	0.78
Category members	DEAD/DEAH_box_helicase_dom	IPR011545	0.35
Category members	Znf_RanBP2	IPR001876	0.18

Protein complexes (CORUM database) featuring ZRANB3

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)

Categories featuring ZRANB3

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0006281	DNA repair	Database	INF
Category members	GO Category	GO:0005524	ATP binding	Database	5.54
Category members	GO Category	GO:0006974	cellular response to DNA damage stimulus	Database	3.57
Category members	GO Category	GO:0004386	helicase activity	Database	2.49
Category members	GO Category	GO:0003677	DNA binding	Database	1.53
Category members	Human mutations	Broad_cancer_genes	Broad cancer genes (Lawrence et al., 2014)	literature	1.14
Category members	GO Category	GO:0003676	nucleic acid binding	Database	0.83
Category members	GO Category	GO:0008026	ATP-dependent helicase activity	Database	0.79
Category members	GO Category	GO:0009411	response to UV	Database	0.79
Category members	GO Category	GO:0070530	K63-linked polyubiquitin binding	Database	0.35
Category members	GO Category	GO:0045910	negative regulation of DNA recombination	Database	0.31
Category members	GO Category	GO:0008270	zinc ion binding	Database	0.29
Category members	GO Category	GO:0043596	nuclear replication fork	Database	0.23
Category members	GO Category	GO:0016787	hydrolase activity	Database	0.22
Category members	GO Category	GO:0036310	annealing helicase activity	Database	0.01
Category members	GO Category	GO:0000733	DNA strand renaturation	Database	0
Category members	GO Category	GO:0004519	endonuclease activity	Database	0
Category members	GO Category	GO:0004520	endodeoxyribonuclease activity	Database	0
Category members	GO Category	GO:0031297	replication fork processing	Database	0
Category members	GO Category	GO:0048478	replication fork protection	Database	0