bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: XPC

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
XPC 3 14.768 -0.140 0.000 2.695 0.925

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
XPC Ubiquitylation K364 4.366 _TSK(gl)GTKQEETFAK_
XPC Ubiquitylation K708 4.328 _MVK(gl)GFSNR_
XPC Ubiquitylation K367 2.553 2.125 _GTK(gl)QEETFAK_
XPC Ubiquitylation K619 1.753 1.740 _EK(gl)KEDLEFQAK_
XPC Ubiquitylation K508 2.971 0.687 _KDPSLPAASSSSSSSK(gl)R_
XPC Ubiquitylation K81 1.419 0.366 _VTVK(gl)SENLK_
XPC Ubiquitylation K650 2.788 -0.207 _NHPLYALK(gl)R_
XPC Ubiquitylation K161 1.308 _SLLPVK(gl)PVEIEIETPEQAK_
XPC Ubiquitylation K174 2.462 _SLLPVKPVEIEIETPEQAK(gl)TR_
XPC Ubiquitylation K374 6.783 _QEETFAK(gl)GTCRPSAK_

Background Information for XPC:


Pubmed-XPC »
Uniprot-XPC »
Biogrid-XPC »
ProteomicsDB-XPC »

Tumorportal-XPC »
COSMIC-XPC »
GenomeRNAi-XPC »
Genecards-XPC


Protein-protein Interactions for XPC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CETN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PHF8 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APLF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CETN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHD1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSNK2A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MACROD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAA40 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAD23B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF146 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPIN2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSEN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR76 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XPC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XRCC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF428 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in XPC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Rad4/PNGase_transGLS-fold IPR018325 0.15


Protein complexes (CORUM database) featuring XPC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring XPC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_857 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER 0 4.24
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members GO Category GO:0000718 nucleotide-excision repair, DNA damage removal Database 3.83
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0031573 intra-S DNA damage checkpoint Database 1.18
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0010224 response to UV-B Database 0.44
Category members GO Category GO:0000404 loop DNA binding Database 0.43
Category members GO Category GO:0000405 bubble DNA binding Database 0.4
Category members GO Category GO:0000715 nucleotide-excision repair, DNA damage recognition Database 0.29


.

© Copyright Svejstrup Laboratory 2015