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Query: VAPA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VAPA 1 4.802 -2.350 3.970 -2.551 0.014 0.056

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VAPA Ubiquitylation K180 1.211 _LMEECK(gl)R_
VAPA Phosphorylation S214 0.747 1.178 _VAHSDKPGS(ph)TSTASFR_
VAPA Ubiquitylation K188 0.176 0.874 _LQGEMMK(gl)LSEENR_

Background Information for VAPA:


Pubmed-VAPA »
Uniprot-VAPA »
Biogrid-VAPA »
ProteomicsDB-VAPA »

Tumorportal-VAPA »
COSMIC-VAPA »
GenomeRNAi-VAPA »
Genecards-VAPA


Protein-protein Interactions for VAPA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP152 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM82A2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait RASSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM170A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCTP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCRN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFYVE27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in VAPA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Vesicle-associated_membrane IPR016763 0.23
Category members MSP_dom IPR000535 0.04
Category members PapD-like IPR008962 0.02


Protein complexes (CORUM database) featuring VAPA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring VAPA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005198 structural molecule activity Database 0.94
Category members GO Category GO:0061025 membrane fusion Database 0.93
Category members GO Category GO:0005923 tight junction Database 0.69
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0031175 neuron projection development Database 0.12
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0070972 protein localization to endoplasmic reticulum Database 0.04
Category members GO Category GO:0031982 vesicle Database 0.01
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_128 REACTOME_SPHINGOLIPID_METABOLISM 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_498 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS 0 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006665 sphingolipid metabolic process Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0030148 sphingolipid biosynthetic process Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0


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