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Query: USP16

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
USP16 0 4.265 -0.680 1.390

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
USP16 Phosphorylation T554 1.067 _NINMDNDLEVLTSSPT(ph)R_
USP16 Phosphorylation S551 0.904 _NINMDNDLEVLTS(ph)SPTR_
USP16 Phosphorylation S415 0.456 0.759 _TVEDEDQDS(ph)EEEKDNDSYIK_
USP16 Phosphorylation S552 0.397 0.707 _NINM(ox)DNDLEVLTSS(ph)PTR_
USP16 Ubiquitylation K37 -0.731 0.604 _GLEQGNLK(gl)K_
USP16 Ubiquitylation K437 0.171 0.056 _SDIPSGTSK(gl)HLQK_
USP16 Ubiquitylation K764 0.748 -1.310 _SGHYTAYAK(gl)AR_

Background Information for USP16:


Pubmed-USP16 »
Uniprot-USP16 »
Biogrid-USP16 »
ProteomicsDB-USP16 »

Tumorportal-USP16 »
COSMIC-USP16 »
GenomeRNAi-USP16 »
Genecards-USP16


Protein-protein Interactions for USP16
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ALPPL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APOM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRPRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in USP16
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UCH/PAN2 IPR028889 0.62
Category members Peptidase_C19_UCH IPR001394 0.53
Category members Znf_UBP IPR001607 0.05


Protein complexes (CORUM database) featuring USP16
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring USP16
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0004843 ubiquitin-specific protease activity Database 3.28
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0004221 ubiquitin thiolesterase activity Database 1.36
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042393 histone binding Database 0.94
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0051289 protein homotetramerization Database 0.44
Category members GO Category GO:0004197 cysteine-type endopeptidase activity Database 0.38
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0070537 histone H2A K63-linked deubiquitination Database 0.11
Category members GO Category GO:0035522 monoubiquitinated histone H2A deubiquitination Database 0.05
Category members GO Category GO:0016578 histone deubiquitination Database 0
Category members GO Category GO:0045901 positive regulation of translational elongation Database 0


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