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Query: UBR5

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
UBR5 1 4.515 0.470 -0.820 -0.310
UBR5 1 4.515 0.470 -0.820 -1.380
UBR5 1 4.515 0.470 -0.820 0.046 0.305 0.536 -0.482

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
UBR5 Ubiquitylation K1248 0.892 _TLIAGQK(gl)SAR_
UBR5 Ubiquitylation K1351 0.012 0.779 _SMIMFGSQENK(gl)DPLSASSR_
UBR5 Phosphorylation S1549 1.569 0.771 _RIS(ph)QSQPVR_
UBR5 Ubiquitylation K1109 0.878 0.766 _ELLSAK(gl)DAR_
UBR5 Ubiquitylation K337 -0.172 0.548 _GSTSK(gl)EGEPNLDKK_
UBR5 Phosphorylation S327 0.474 0.437 _WLDGAS(ph)FDNER_
UBR5 Ubiquitylation K672 -0.561 -0.090 _VLK(gl)VDGAYVAVK_
UBR5 Ubiquitylation K583 -0.122 _SPESLK(gl)NMEK_
UBR5 Ubiquitylation K587 -0.122 _SPESLK(gl)NMEK_
UBR5 Phosphorylation S2026 -1.786 -1.571 _RS(ph)DSM(ox)TFLGCIPPNPFEVPLAEAIPLADQPHLLQPNAR_
UBR5 Ubiquitylation K346 -0.580 _EGEPNLDKK(gl)_
UBR5 Ubiquitylation K423 -1.074 _ATFLGLTNEK(gl)_

Background Information for UBR5:


Pubmed-UBR5 »
Uniprot-UBR5 »
Biogrid-UBR5 »
ProteomicsDB-UBR5 »

Tumorportal-UBR5 »
COSMIC-UBR5 »
GenomeRNAi-UBR5 »
Genecards-UBR5


Protein-protein Interactions for UBR5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BUB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1B Cat. description Hein, Mann, Cell 2015
Category members IP bait C20orf172;DSN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP78 Cat. description Hein, Mann, Cell 2015
Category members IP bait GEMIN5 Cat. description Hein, Mann, Cell 2015
Category members IP bait JAK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF2A Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MGP Cat. description Hein, Mann, Cell 2015
Category members IP bait NES Cat. description Hein, Mann, Cell 2015
Category members IP bait UBR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CALR3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait F9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HNRPLL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYZL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POGLUT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPAN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRMT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRSS37 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in UBR5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RCC1/BLIP-II IPR009091 0.24
Category members HECT IPR000569 0.04
Category members PABP_HYD IPR002004 0
Category members Znf_N-recognin IPR003126 0
Category members Znf_N-recognin_met IPR013993 0


Protein complexes (CORUM database) featuring UBR5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1335 SNW1 complex Database 3.59


Categories featuring UBR5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0033160 positive regulation of protein import into nucleus, translocation Database 0.04
Category members GO Category GO:0035413 positive regulation of catenin import into nucleus Database 0.02
Category members GO Category GO:0034450 ubiquitin-ubiquitin ligase activity Database 0
Category members GO Category GO:0050847 progesterone receptor signaling pathway Database 0


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