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Query: UBA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
UBA1 0 3.299 0.090 -0.310 0.251 -0.973 0.799 0.602

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
UBA1 Ubiquitylation K185 0.243 1.274 _GIK(gl)LVVADTR_
UBA1 Phosphorylation S46 0.482 0.545 _NGS(ph)EADIDEGLYSR_
UBA1 Ubiquitylation K528 -0.599 0.237 _LK(gl)SDTAAAAVR_
UBA1 Ubiquitylation K296 0.188 _GGIVSQVK(gl)VPK_
UBA1 Ubiquitylation K593 -0.196 0.152 _K(gl)PLLESGTLGTK_
UBA1 Phosphorylation S835 -0.322 -0.079 _ATLPS(ph)PDKLPGFK_
UBA1 Ubiquitylation K671 -0.518 -0.212 _QPAENVNQYLTDPK(gl)FVER_
UBA1 Ubiquitylation K68 0.319 _QLYVLGHEAMK(gl)R_
UBA1 Ubiquitylation K465 -0.360 _YDGQVAVFGSDLQEK(gl)LGK_
UBA1 Ubiquitylation K746 -0.514 _QLLHNFPPDQLTSSGAPFWSGPK(gl)R_
UBA1 Ubiquitylation K802 -1.053 _AAVATFLQSVQVPEFTPK(gl)SGVK_
UBA1 Ubiquitylation K884 -0.047 _AENYDIPSADRHKSK(gl)_

Background Information for UBA1:


Pubmed-UBA1 »
Uniprot-UBA1 »
Biogrid-UBA1 »
ProteomicsDB-UBA1 »

Tumorportal-UBA1 »
COSMIC-UBA1 »
GenomeRNAi-UBA1 »
Genecards-UBA1


Protein-protein Interactions for UBA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait UBA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2K Cat. description Hein, Mann, Cell 2015
Category members IP bait USP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in UBA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UBQ/SUMO-activ_enz_E1-like IPR000011 0.29
Category members ThiF_NAD_FAD-bd IPR000594 0.19
Category members Molybdenum_cofac_synth_MoeB IPR009036 0.19
Category members UBact_repeat IPR000127 0.08
Category members Ubiquitin-activating_enzyme IPR019572 0.08
Category members UBQ-activ_enz_E1 IPR018075 0.05
Category members Ub-activating_enz_e1_C IPR018965 0.05


Protein complexes (CORUM database) featuring UBA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring UBA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members Pathway Pathway_467 BIOCARTA_PROTEASOME_PATHWAY 0 0.82
Category members GO Category GO:0008641 small protein activating enzyme activity Database 0.26
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members Pathway Pathway_31 KEGG_PARKINSONS_DISEASE 0 0
Category members GO Category GO:0006464 cellular protein modification process Database 0
Category members GO Category GO:0016874 ligase activity Database 0


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