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Query: TXNIP

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TXNIP 0 -2.136

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TXNIP Ubiquitylation K26 -0.901 -1.235 _VYGSGEK(gl)VAGR_

Background Information for TXNIP:


Pubmed-TXNIP »
Uniprot-TXNIP »
Biogrid-TXNIP »
ProteomicsDB-TXNIP »

Tumorportal-TXNIP »
COSMIC-TXNIP »
GenomeRNAi-TXNIP »
Genecards-TXNIP


Protein-protein Interactions for TXNIP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RGMA Cat. description Hein, Mann, Cell 2015
Category members IP bait IL12RB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TXNIP
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring TXNIP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TXNIP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_1203 REACTOME_INFLAMMASOMES 0 0.5
Category members GO Category GO:0005758 mitochondrial intermembrane space Database 0.33
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0009612 response to mechanical stimulus Database 0.23
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members Pathway Pathway_1204 REACTOME_THE_NLRP3_INFLAMMASOME 0 0.2
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members GO Category GO:0051782 negative regulation of cell division Database 0.17
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members GO Category GO:0032570 response to progesterone Database 0.1
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0004857 enzyme inhibitor activity Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0032355 response to estradiol Database 0
Category members GO Category GO:0043086 negative regulation of catalytic activity Database 0
Category members GO Category GO:0048008 platelet-derived growth factor receptor signaling pathway Database 0
Category members GO Category GO:0051592 response to calcium ion Database 0


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