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Query: TRIM23

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TRIM23 0 0.613 -0.430 -0.320

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TRIM23 Ubiquitylation K357 0.933 _VVLAK(gl)QEITR_
TRIM23 Ubiquitylation K501 0.711 _LLTEK(gl)ELR_
TRIM23 Ubiquitylation K8 -1.906 _(ac)ATLVVNK(gl)LGAGVDSGR_

Background Information for TRIM23:


Pubmed-TRIM23 »
Uniprot-TRIM23 »
Biogrid-TRIM23 »
ProteomicsDB-TRIM23 »

Tumorportal-TRIM23 »
COSMIC-TRIM23 »
GenomeRNAi-TRIM23 »
Genecards-TRIM23


Protein-protein Interactions for TRIM23
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TRIM23 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TRIM23
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Znf_C2H2 IPR007087 0.92
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Small_GTPase IPR001806 0.65
Category members Gtr1_RagA IPR006762 0.63
Category members Small_GTPase_Rab_type IPR003579 0.51
Category members MIRO-like IPR013684 0.4
Category members Small_GTP-bd_dom IPR005225 0.32
Category members Bbox_C IPR003649 0.18
Category members SRP_receptor_beta_su IPR019009 0.13
Category members Gprotein_alpha_su IPR001019 0.02
Category members Znf_B-box IPR000315 0
Category members Znf_RING IPR001841 0
Category members Small_GTPase_SAR1 IPR006687 0
Category members Znf_C3HC4_RING-type IPR018957 0
Category members Small_GTPase_ARF IPR024156 0


Protein complexes (CORUM database) featuring TRIM23
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 702 ARD1-NATH complex Database 0


Categories featuring TRIM23
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0043085 positive regulation of catalytic activity Database 0.78
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0019003 GDP binding Database 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0008047 enzyme activator activity Database 0.15
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0019001 guanyl nucleotide binding Database 0.07
Category members GO Category GO:0031683 G-protein beta/gamma-subunit complex binding Database 0.02
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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