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Query: TOP1MT

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TOP1MT 2 7.944 1.650 -0.670 0.567 0.872 1.232 0.631 0.425

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TOP1MT Ubiquitylation K252 1.900 _LSPK(gl)AEEVATFFAK_
TOP1MT Ubiquitylation K245 2.277 _FYYDGK(gl)VMK_
TOP1MT Ubiquitylation K391 0.019 _DAK(gl)VPSPPPGHK_
TOP1MT Ubiquitylation K545 2.178 _YYNKVPVEK(gl)R_
TOP1MT Ubiquitylation K642 2.317 _TFEK(gl)SMMNLQTK_

Background Information for TOP1MT:


Pubmed-TOP1MT »
Uniprot-TOP1MT »
Biogrid-TOP1MT »
ProteomicsDB-TOP1MT »

Tumorportal-TOP1MT »
COSMIC-TOP1MT »
GenomeRNAi-TOP1MT »
Genecards-TOP1MT


Protein-protein Interactions for TOP1MT
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CENPE Cat. description Hein, Mann, Cell 2015
Category members IP bait LEO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAGEA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUPL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PQBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPS1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TFG Cat. description Hein, Mann, Cell 2015
Category members IP bait TNPO1 Cat. description Hein, Mann, Cell 2015


Protein Domains in TOP1MT
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TopoI IPR001631 0.05
Category members TopoI_DNA-bd_euk IPR008336 0.05
Category members DNA_brk_join_enz IPR011010 0.05
Category members TopoI_euk IPR013499 0.05
Category members TopoI_cat_euk IPR013500 0.05


Protein complexes (CORUM database) featuring TOP1MT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TOP1MT
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0006265 DNA topological change Database 1.92
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0042645 mitochondrial nucleoid Database 0.61
Category members GO Category GO:0003917 DNA topoisomerase type I activity Database 0.39
Category members GO Category GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity Database 0.39


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