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Query: TET2

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TET2 0 -0.091 0.550 -0.710
TET2 0 -0.091 0.680 -0.450

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TET2 Phosphorylation S120 -0.232 0.141 _TVS(ph)EPSLSGLLQIK_

Background Information for TET2:


Pubmed-TET2 »
Uniprot-TET2 »
Biogrid-TET2 »
ProteomicsDB-TET2 »

Tumorportal-TET2 »
COSMIC-TET2 »
GenomeRNAi-TET2 »
Genecards-TET2


Protein-protein Interactions for TET2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NONO Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TET2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TET2
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring TET2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TET2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0006493 protein O-linked glycosylation Database 0.32
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Disease phenotype Essential_thrombocythemia Essential thrombocythemia Database 0
Category members Disease phenotype MYELODYSPLASTIC_SYNDROME MYELODYSPLASTIC SYNDROME Database 0
Category members Disease phenotype Myelofibrosis_with_myeloid_metaplasia Myelofibrosis with myeloid metaplasia Database 0
Category members Disease phenotype POLYCYTHEMIA_VERA POLYCYTHEMIA VERA Database 0
Category members GO Category GO:0001822 kidney development Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0030097 hemopoiesis Database 0
Category members GO Category GO:0030099 myeloid cell differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0070579 methylcytosine dioxygenase activity Database 0


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