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Query: TCF12

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TCF12 0 1.283 0.940 -0.150

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TCF12 Phosphorylation S559 0.763 0.520 _TSS(ph)TNEDEDLNPEQK_
TCF12 Phosphorylation S385 -0.190 -0.444 _PGGQAPS(ph)SPSYENSLHSLQSR_

Background Information for TCF12:


Pubmed-TCF12 »
Uniprot-TCF12 »
Biogrid-TCF12 »
ProteomicsDB-TCF12 »

Tumorportal-TCF12 »
COSMIC-TCF12 »
GenomeRNAi-TCF12 »
Genecards-TCF12


Protein-protein Interactions for TCF12
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GET4 Cat. description Hein, Mann, Cell 2015
Category members IP bait ID1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ID2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KCTD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait SGOL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZWINT Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC101 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FERD3L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HEXIM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ID2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MESP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYOG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEUROD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NEUROG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TCF12
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32


Protein complexes (CORUM database) featuring TCF12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2937 PTF1-bHLH complex Database 0


Categories featuring TCF12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_1038 REACTOME_MYOGENESIS 0 0
Category members Disease phenotype Extraskeletal_myxoid_chondrosarcoma Extraskeletal myxoid chondrosarcoma Database 0
Category members Disease phenotype Isolated_brachycephaly Isolated brachycephaly Database 0
Category members Disease phenotype Isolated_plagiocephaly Isolated plagiocephaly Database 0
Category members GO Category GO:0007517 muscle organ development Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0070888 E-box binding Database 0


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