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Query: TCEB1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TCEB1 0 -0.339 0.480 -0.460 0.004 -1.523 0.284

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TCEB1 Ubiquitylation K32 0.313 0.583 _LISSDGHEFIVK(gl)R_
TCEB1 Ubiquitylation K72 -0.158 _EIPSHVLSK(gl)_

Background Information for TCEB1:


Pubmed-TCEB1 »
Uniprot-TCEB1 »
Biogrid-TCEB1 »
ProteomicsDB-TCEB1 »

Tumorportal-TCEB1 »
COSMIC-TCEB1 »
GenomeRNAi-TCEB1 »
Genecards-TCEB1


Protein-protein Interactions for TCEB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATRX Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait CTDSPL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait ECD Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXO7 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ILK Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF19 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MSN Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH6 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCSTN Cat. description Hein, Mann, Cell 2015
Category members IP bait SGOL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TCEB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASB6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASB9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CUL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB40A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB40AL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB40B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SOCS6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VHL Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TCEB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BTB/POZ_fold IPR011333 0.36
Category members Skp1_comp IPR001232 0.13
Category members Skp1_comp_POZ IPR016073 0.13


Protein complexes (CORUM database) featuring TCEB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 205 Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2, RBX1) Database 0
Category members Corum 207 Ubiquitin E3 ligase (ASB2, TCEB1, TCEB2, CUL5, RNF7) Database 0
Category members Corum 208 Ubiquitin E3 ligase (ASB1, TCEB1, TCEB2, CUL5, RNF7) Database 0
Category members Corum 209 Ubiquitin E3 ligase (ASB6, TCEB1, TCEB2, CUL5, RNF7) Database 0
Category members Corum 210 Ubiquitin E3 ligase (ASB7, TCEB1, TCEB2, CUL5, RNF7) Database 0
Category members Corum 211 Ubiquitin E3 ligase (ASB12, TCEB1, TCEB2, CUL5, RNF7) Database 0
Category members Corum 214 Ubiquitin E3 ligase (WSB1, TCEB1, TCEB2, CUL5, RBX1) Database 0
Category members Corum 5267 VHL-VDU1-TCEB1-TCEB2 complex Database 0
Category members Corum 5270 VHL-TCEB1-TCEB2 complex Database 0
Category members Corum 622 Ubiquitin E3 ligase (VHL, TCEB1, TCEB2, CUL2) Database 0


Categories featuring TCEB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members GO Category GO:0050434 positive regulation of viral transcription Database 4.8
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members Pathway Pathway_360 REACTOME_FORMATION_OF_RNA_POL_II_ELONGATION_COMPLEX_ 0 3.35
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0006368 transcription elongation from RNA polymerase II promoter Database 2.03
Category members Pathway Pathway_363 REACTOME_RNA_POL_II_PRE_TRANSCRIPTION_EVENTS 0 1.84
Category members Pathway Pathway_367 REACTOME_ELONGATION_ARREST_AND_RECOVERY 0 1.67
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members Pathway Pathway_796 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G 0 1.14
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter Database 0.99
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_753 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN 0 0.35
Category members GO Category GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia Database 0.32
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members Pathway Pathway_821 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_976 PID_HIF1A_PATHWAY 0 0
Category members GO Category GO:0030891 VCB complex Database 0
Category members GO Category GO:0070449 elongin complex Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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